A novel one-pot tandem synthesis of 2-styryl-4(3 H)-quinazolinones in an acidic ionic liquid is reported. In this procedure isatoic anhydride, a primary aniline or ammonium acetate, and triethylorthoacetate are reacted in the presence of imidazolium trifluoroacetate [Hmim]TFA. Subsequently an aromatic aldehyde is added to the mixture to afford the title compounds in high to excellent yields.

Carbamatoalkylnaphthol derivatives (IV) are easily synthesized via a three-component reaction of naphthol (I), aromatic aldehydes (II) and methyl carbamate (III) in ionic liquid media. The reaction fails for aldehydes bearing electron-donating substituents. Ring closure of (IV) occurs at elevated temperatures to afford title compounds (V) in good yields. The reaction sequence can also be performed as one-step synthesis. -(DABIRI, M.; DELBARI, A. S.; BAZGIR*, A.; Heterocycles 71 (2007) 3, 543-548; Dep. Chem., Fac. Sci., Shahid Beheshti Univ., Tehran, Iran; Eng.) -M. Paetzel 30-135

Novel pyrimido [4,5-b]quinoline-tetraones were prepared by the three-component reaction of 2-hydroxynaphthalene-1,4-dione, 6-amino-uracils, and aromatic aldehydes in aqueous media and catalyzed by p-toluenesulfonic acid. This protocol provides a simple one-step procedure with the advantages of easy workup, good yield of products, and environmental friendliness.

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