No abstract

MicroRNAs (miRNAs) are small noncoding RNAs that regulate the translation of mRNA and protein, mainly at the posttranscriptional level. Global expression profiling of miRNAs has demonstrated a broad spectrum of aberrations that correlated with several diseases, and miRNA-10a and miRNA-10b were the first examined miRNAs to be involved in abnormal activities upon dysregulation, including many types of cancers and progressive diseases. It is expected that the same miRNAs behave inconsistently within different types of cancer. This review aims to provide a set of information about our updated understanding of miRNA-10a and miRNA-10b and their clinical significance, molecular targets, current research gaps, and possible future applications of such potent regulators.

: MicroRNAs “miRNAs” are small non-coding RNAs that regulate translation of mRNA and protein mainly on post-transcriptional level. And as global expression profiling of miRNAs has demonstrated a wide spectrum of aberration that are correlated with several diseases, miRNA-10a/b were of the first miRNAs to be examined to be involved in abnormal activities upon dysregulation, including many types of cancers and progressive diseases. It is expected for the same miRNAs to behave in an inconsistent fashion within different types of cancers, or even in the same type upon different contexts or phases. This review is an attempt to provide a set of information about our updated understanding of miRNA-10a/b and their clinical significance, molecular targets, current research gaps and possibly future applications of such potent regulators, and help to uncover the logic behind such behavior and possible approaches to exploit such unique entities.