Background: Worldwide different plants were studied for their role in the treatment and correction of different types of anaemia's. The Medicinal and Aromatic Plants Research Institute (MAPRI) of the National Centre for Research (NCR) plays major role in medicinal and aromatic plants investigation, determination of therapeutic properties and documented in Sudan.Objectives: This study used to determine the effect of Cajanus Cajan seeds extract on the some haematological parameters among hemorrhagic anaemia rats, Khartoum -Sudan.Methods: Experimental randomised controlled trial study conducted among 24 healthy Wistar albino rats with both sex, ages (6weeks) and weighing between (75-130g), they were feed with standard laboratory chow. they divided into four groups each one consists of six rats.Result: Dose group(800 mg/kg/day) represent highly significant increases in haemoglobin in W0&W1 P value < 0.001,and W0&W3 p value is 0.0002.while the dose of 400mg/kg/day significant increase in W0&W1 p value is< 0.003 and W0&W3 p<0.00004, in the dose of 200mg/kg/day represent also significant increase at W0&W1 p<0.005 and in W0&W3p<0.007 respectively, when compared to control values(Group1). Conclusion:This study revealed that there are increased in some haematological parameters and lend support to the use of ethanol seeds extract of Cajanus Cajan in treatment of hemorrhagic anaemia.

No abstract

Background: Urothelial (transitional cell) bladder carcinoma UBC is the most common malignancy of the urinary tract and the seventh leading cancer in men worldwide. Mutations in P53 gene are the most common genetic abnormality inhuman cancer. Mutation of P53 gene results P53protein accumulation in cells' nuclei. This accumulation is detectable with Immunohistochemical methods and correlates with P53 gene mutation. Aims: The study aimed to detect the expression of p53 in Urothelium cell carcinoma of urinary bladder using Immunohistochemical method, and correlate the expression of p53 with the gender, age of patient and histological grade. Methods: Forty paraffin embedded blocks previously diagnosed as transitional cell carcinoma were collected. This retrospective analytical study conducted at,

Objectives. This is a case controls study used to determine the frequency of Interleukin-6 (-174 G/C) and hepcidin HAMP (-582A/G) gene polymorphisms among Sudanese patients with anemia of chronic kidney disease treated with erythropoietin by using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR/RFLP). Results. Significantly decreased levels in RBCS profile: RBCs count, Hb and PCVin patients with CKD and RBCS profile were observed. The polymorphisms (SNP) of the IL-6 gene and hepcidin (HAMP) gene promoter in Sudanese patients with ACKD were showed. the IL-6 (-174G/C) (SNP) was present in the hepcidin HAMP (-582A/G) (SNP) AA genotype 70 (35%), AG 23 (11.5) and GG 7 (3.5%) in 100 patients dialysis dependent and AA 166 (41.5%), AG 34 (8.5%) and GG 0 (0%) in 200 control subjects, and the allele A are more frequent in patients affected by ACKD.

No abstract