Background: Pancreatic panniculitis is a rare entity, occurring in less than 2% of patients with pancreatic disorders. Skin manifestations may precede the diagnosis of a pancreatic disease by many months. When treatable, correction of the underlying pancreatic disorder may lead to prompt resolution of the panniculitis.Objective: We present the case of a 74-year-old-man with a history of chronic pancreatitis who presented with an acute onset of tender, nonulcerating nodules. The clinical and histologic features of pancreatic panniculitis are discussed, with a brief review of the differential diagnosis and clinical approach to panniculitis.Conclusions: Pancreatic panniculitis is a recognizable clinical entity with characteristic histologic features that may resolve with treatment of the underlying pancreatic disorder. The algorithm-based clinical approach to panniculitis presented in this study is a practical tool designed to guide clinicians in ordering investigations and determining the appropriate management for patients presenting with subcutaneous nodules.Anté cé dents: La panniculite pancré atique est une condition rare qui survient chez moins de 2 % des patients souffrant d'un trouble du pancré as. Les manifestations cutané es peuvent pré cé der de plusieurs mois le diagnostic d'une maladie du pancré as. Le traitement de la maladie du pancré as sous-jacente, lorsque cette maladie est traitable, peut mener à une prompte gué rison de la panniculite.Objectif: Pré senter le cas d'un homme de 74 ans ayant des anté cé dents de pancré atite chronique qui pré sente une manifestation de nodules douloureux et non ulcé reux. Les caracté ristiques cliniques et histologiques de la panniculite pancré atique sont exposé es, avec un survol rapide du diagnostic diffé rentiel et de l'approche clinique de la panniculite.Conclusions: La panniculite pancré atique est une condition repé rable qui pré sente des caracté ristiques histologiques pré cises et qui peut gué rir à la suite du traitement de la maladie du pancré as sous-jacente. L'approche clinique se fondant sur un algorithme pré senté dans cette é tude repré sente un outil pratique visant à guider les cliniciens dans leur investigation et dans le choix du moyen de gestion approprié des malades pré sentant des nodules sous-cutané s.

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As an outcome measure in intervention trials, the finely grained risk score is more sensitive than the trinary risk classification. The additional clinical value of the risk score relative to the categorical measure needs to be determined.

We present a rare case of a 61-year-old woman presenting with a widespread erosive eruption on her torso and extremities. Although the lesions were histologically compatible with toxic epidermal necrolysis, clinically the patient was hemodynamically stable, had no mucosal involvement and had no relevant medical history or potentially incriminating medications. Further investigations uncovered a new diagnosis of systemic lupus erythematosus, with this toxic epidermal necrolysis–like eruption being the first presentation of the disease. This case highlights the importance of broadening the differential diagnosis in patients presenting with acute widespread cleavage of the epidermis, using the spectrum of acute syndrome of apoptotic pan-epidermolysis as a reference.