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The rise in obesity rates, both nationally and internationally, is a result of changes in the environment that have simultaneously lowered the cost of food production, lowered the time and monetary cost of food consumption, increased the real cost of being physically active at work and at home, and decreased the health consequences that result from obesity by bringing a host of new drugs and devices to the market to better manage the adverse health effects that obesity promotes. This changing environment is in response to consumers' demand for labor-saving technology and convenient, affordable food. To be successful, efforts to combat obesity therefore need to recognize and address these realities.

Results suggest that front-of-package nutrition labels are likely to influence purchasing patterns. This trial was registered at www.clinicaltrials.gov as NCT03390075.

Key Points Question What are the associations between specific adolescent cognitive abilities and Alzheimer disease and related disorders in later life? Findings In this cohort study of 43 014 men and 42 749 women, lower adolescent memory for words, in women, and lower mechanical reasoning, in men, were associated with higher odds of Alzheimer disease and related disorders in later life. Meaning Low performance on certain specific measures of cognitive ability may indicate future risk of Alzheimer disease and related disorders as early as adolescence.

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