Objective This retroactive meta-analysis assesses the relationship between Mycobacterium avium subspecies paratuberculosis (MAP) and Crohn's Disease (CD). Methods A meta-analysis of PCR- and culture-based studies were conducted to determine if there is a relationship between MAP and Crohn's Disease. The chi-squared test of independence was also conducted to determine if MAP infection and Crohn's disease onset are independent events. Results The studies analyzed were able to provide evidence that Mycobacterium avium subspecies paratuberculosis is highly associated with Crohn's disease. It is also shown that, regardless of the detection method, MAP can effectively be detected in Crohn's patients. Conclusion MAP is strongly connected with Crohn's Disease.

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The Quality Control (QC) Department in a grease plant is vital to product compliance and customer satisfaction. QC provides the initial inspection of raw materials and finished goods which determines whether the material is acceptable for manufacture or sale. In other words, the QC department is the gateway to customer satisfaction and future accounts. In order to have a successful QC department, the following key factors must be met: properly trained personnel, suitable inspection equipment and a functioning management system. If these three factors are established and continually improved, the QC Department will be effective.

Herein is described a method to develop a QSAR model to predict the molecular inhibition of human STAT3. The model was built using machine learning using Python 3.3. A random forest machine learning algorithm was deployed. The model produced a R2 value of 0.86, indicating that our QSAR model is effective at predicting inhibitory compounds of STAT3.