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Intracranial hemorrhage occurs when blood vessels rupture or leak within the brain tissue or elsewhere inside the skull. It can be caused by physical trauma or by various medical conditions and in many cases leads to death. The treatment must be started as soon as possible, and therefore the hemorrhage should be diagnosed accurately and quickly. The diagnosis is usually performed by a radiologist who analyses a Computed Tomography (CT) scan containing a large number of crosssectional images throughout the brain. Analysing each image manually can be very time-consuming, but automated techniques can help speed up the process. While much of the recent research has focused on solving this problem by using supervised machine learning algorithms, publicly-available training data remains scarce due to privacy concerns. This problem can be alleviated by unsupervised algorithms. In this paper, we propose a fullyunsupervised algorithm which is based on the mixture models. Our algorithm utilizes the fact that the properties of hemorrhage and healthy tissues follow different distributions, and therefore an appropriate formulation of these distributions allows us to separate them through an Expectation-Maximization process. In addition, our algorithm is able to adaptively determine the number of clusters such that all the hemorrhage regions can be found without including noisy voxels. We demonstrate the results of our algorithm on publicly-available datasets that contain all different hemorrhage types in various sizes and intensities, and our results are compared to earlier unsupervised and supervised algorithms. The results show that our algorithm can outperform the other algorithms with most hemorrhage types.

Healthcare big data remains under-utilized due to various incompatibility issues between the domains of data analytics and healthcare. The lack of generalizable iterative feature acquisition methods under budget and machine learning models that allow reasoning with a model’s uncertainty are two examples. Meanwhile, a boost to the available data is currently under way with the rapid growth in the Internet of Things applications and personalized healthcare. For the healthcare domain to be able to adopt models that take advantage of this big data, machine learning models should be coupled with more informative, germane feature acquisition methods, consequently adding robustness to the model’s results. We introduce an approach to feature selection that is based on Bayesian learning, allowing us to report the level of uncertainty in the model, combined with false-positive and false-negative rates. In addition, measuring target-specific uncertainty lifts the restriction on feature selection being target agnostic, allowing for feature acquisition based on a target of focus. We show that acquiring features for a specific target is at least as good as deep learning feature selection methods and common linear feature selection approaches for small non-sparse datasets, and surpasses these when faced with real-world data that is larger in scale and sparseness.

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