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Epizootic lymphangitis (EL) compromises the welfare of working horses and has a serious negative impact on the livelihoods of cart horse owners/drivers in the affected parts of Ethiopia. Unfortunately, antifungal drugs for the treatment of EL are unavailable in both private and government clinics. The spread of multidrug-resistant strains of fungi motivates to discover new classes of antifungal compounds that inhibit these resistant strains. Therapeutic alternative compounds, particularly those isolated from plants have shown promising empirical effect on different fungal strains, which are unresponsive to chemical anti fungi drugs. Histoplasma capsulatum var farciminosum obtained from Aklilu Lema Institue of Patho Biology (ALIPB) was used as test organism. Agar dilution assay was performed to evaluate the inhibitory effect of Combretum molle seed extract and to measure the minimum inhibitory concentration (MIC). Ketaconazole was used as a positive control. Combretum molle seed extracts inhibit the growth of HCF up to 0.0156%. Hydrolysable tannins have a great potential in inhibition of fungal growth. In case of topical application, tannins have haemostatic effect and wound closure property.

A study was conducted to identify the current status of Fasciola infections in small ruminants in Kutaber. A total of 392 faecal samples from small ruminants were collected and subjected to sedimentation technique. Out of 392 faecal samples inspected, 133(33.9%) were positive for Fasciola. Prevalence of 50.7%, 24.3% and 21.5% were observed in poor, medium and good body condition respectively. In young and adult sheep prevalence of 29.8% and 35.2% were identified from faecal samples inspected respectively. The prevalence of Fasciolosis was various in different study areas. The highest prevalence was observed in Lewcho (45.6%) followed by Alansha (41.9%), Beshilo (30.0%), Doshign (29.0%), and Elsa (20.0%).When body condition was considered as a risk factor for the prevalence of Fasciolosis 50.7 %, 24.3% and 21.5% was found in poor, medium and good body condition respectively. The prevalence of Fasciolosis in male (24.0%) and female (23.9%) animal was recorded. Risk factors such as locality, age, body condition and sex did not show statistically significant variation on the prevalence of Fasciolosis (P>0.05).

A study was conducted to identify the current status of Paramphisthomum infections in small ruminants in Kutaber. A total of 384 fecal samples from small ruminants were collected and subjected to sedimentation technique. Out of 384 fecal samples inspected, 150 (39.1%) were positive for Paramphisthomum. The prevalence rates of 36.5 and 30.8% were observed in good and medium body condition, respectively. In adult and young sheep, the prevalence rates of 40.9 and 33.3 were identified from fecal samples inspected, respectively. The highest prevalence of Paramphistomiasis was observed in Lewcho (50.0%) followed by Beshilo (44.5%) and Elsa (42.1%) The lowest incidence of Paramphistomiasis was observed in Alansha (19.0%). Based on age groups, the highest prevalence rate was 40.9% observed in age category of adult and the lowest prevalence rate 33.3% was observed in young. When body condition was considered as a risk factor for the prevalence of Paramphistomiasis, 49.5, 30.8 and 36.5% was observed in poor, medium and good body condition respectively. The prevalence of Paramphistomiasis in male (33.9%) and female (41.3%) was recorded. This parasitic disease is distributed in every district and considered as one of the major setbacks to sheep product utilization causing direct and indirect losses.