Ischemic stroke is still leading in terms of primary disability caused by residual neurologic de-fect in the majority of patients. Persistent motor disorders are observed even after timely and ade-quately carried out rehabilitation measures. The article discusses the possibilities of modern instru-mental technologies for diagnostics and further monitoring of the process of restoration of post-stroke deficit, which is based on the phenomenon of neuroplasticity.

The review presents modern data on epidemiology, mechanisms of pathogenesis, clinical presentation, diagnosis of radicular pain. The indications for surgical treatment, the causes of failures in the treatment of radicular pain syndrome and the issues of its chronicity, as well as the prevention of the development of chronic pain of lumbosacral localization are considered. A generalized list of predictors of outcomes of surgical treatment of radicular pain is presented. Criteria for stage-by-stage diagnostics, physical and instrumental examination of patients with radicular pain in the lower back are presented. Conditions aimed at expanding the range of diagnostic studies, the feasibility of a multidisciplinary approach to the treatment of patients with pain in lumbosacral localization are discussed.

al.] Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A. British Journal of Pharmacology. 2015;172:515-531. 20. Smith E. S., Lewin G. R. Nociceptors: a phylogenetic view. J. Comp. Physiol. A. Neuroethol. Sens. Neural. Behav. Physiol. 2009;195(12) A comprehensive examination of 114 patients with stage I and II hypertension was carried out. The aim of the study was to develop a modern, pathogenetically substantiated, comprehensive non-medicamentous method of curative correction of early cerebral manifestations of hypertension. The main correction of the initial manifestations of hypertension was a special technique of curative gymnastics and respiratory gymnastics with elements of group psychotherapy. Group 1 (n=80) -patients who received complex non-drug treatment; Group 2 (n=34) -patients who received drug-induced antihypertensive therapy on the basis of monotherapy or low-dose combination therapy. Patients of the 1 st group reported a significant (p<0.01) improvement after the end of treatment. Intergroup differences obtained before and after treatment, in patients of the 1 st and 2 nd groups it had a significant (p<0.01) nature. The study of cerebral hemodynamics significantly (p<0.01) indicated an increase in the majority of patients of the 1st group of blood flow along the vertebral arteries, the posterior cerebral arteries. In the state of vasomotor reactivity and autoregulation of cerebral blood flow, there was significant (p<0.01) positive dynamics only in patients of the 1st group. Thus, the analysis of the results of our algorithm for treating patients with initial manifestations of hypertension, conducted with the use of non-drug methods, demonstrates the validity of the proposed pathogenetic approach to ongoing therapy. Keywords: arterial hypertension, therapy, combined therapy, nonmedical methodsБыло проведено комплексное обследование 114 пациентов с АГ I и II стадии. Цель исследования -раз-работать современный патогенетически обоснованный комплексный немедикаментозный метод лечебной коррекции ранних церебральных проявлений артериальной гипертензии (АГ). Основой коррекции начальных проявлений АГ являлась специальная методика лечебной гимнастики и дыхательной гимнастики с элемен-тами групповой психотерапии. 1-я группа (n=80) -пациенты, получавшие комплексное немедикаментозное лечение; 2-я группа (n=34) -пациенты, получавшие медикаментозную гипотензивную терапию на основе монотерапии или низкодозированной комбинированной терапии. Пациенты 1-й группы отмечали достовер-ное (p<0,01) улучшение после окончания лечения. Исследование церебральной гемодинамики достоверно (p<0,01) свидетельствовало об улучшении мозгового кровотока. В состоянии вазомоторной реактивности и ауторегуляции мозгового кровотока также отмечалась достоверная (p<0,01) положительная динамика только

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