FAMILIAL NEPHRITIS. A VARIANT OF ALPORT'S SYNDROEiE?1125 Nina B. Vicente. Cinyar B. Bhathena and Nancy 11. I F b .Medical C e n t e r , i n g t o n . In all, seizures were initially focal with progreasion to generalized myoclonus; 3 had multiple seizures while on therapy. No child had previous seizures while on steroid therapy alone except one who had a seizure with hypertensive encaphalopathy 4 yrs previously. No child had hypertension, fever or metabolic abnormality at the tima of seizures. Lumbar puncture in 4 was within normal limits. EEG showed focal changes in 5 and diffuse slowing in onel follow-up EEG in 4 had returned to normal. No child had persistence of seizure activity after chlorambucil discontinued. Kentucky. A fonn o f familial nephritis with many features distinct: fromEven though seizure activity can not be related to age, duration of illness, sex, dosage, duration of treatment, or underlying disease, chlorambucil appears to be implicated as a contributing factor to these seizures.

Fifteen children with the clinical manifestations of hemolytic-uremic syndrome are reported.Prompt recognition of the syndrome and effective therapy for acute renal failure including early dialysis were institured in each case. Analysis of the clinical course and histopathologic features in these patients indicated that early dialysis and effective management of acute renal failure may unmask evidence of nonrenal involvement; microthrombi may be found in a wide distribution of organs, including the brain and myocardium; and extent and severity of nonrenal involvement become an important determinant of ultimate prognosis.

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o n c e n t r a t i o n o f i n a c t i v e r e n i n i s h i g h i n t h e newborn a t a t i m e hen c i r c u l a t i n g a c t i v e r e n i n l e v e l s a r e known t o be elevated, nd whether i n a c t i v e newborn r e n i n can be separated from a c t i v e e n i n by chromatography. 78 samples o f newborn plasma were c i d i f i e d t o ph 5.5-5.7, t h e optimal ph f o r g e n e r a t i n g angioteni n I (angio I ) from a c t i v e r e n i n , and t r e a t e d w i t h Bal and 8-OH u i n o l i n e t o prevent f o r m a t i o n o f a n g i o t e n s i n 2. The samples