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FAMILIAL NEPHRITIS. A VARIANT OF ALPORT'S SYNDROEiE?1125 Nina B. Vicente. Cinyar B. Bhathena and Nancy 11. I F b .Medical C e n t e r , i n g t o n . In all, seizures were initially focal with progreasion to generalized myoclonus; 3 had multiple seizures while on therapy. No child had previous seizures while on steroid therapy alone except one who had a seizure with hypertensive encaphalopathy 4 yrs previously. No child had hypertension, fever or metabolic abnormality at the tima of seizures. Lumbar puncture in 4 was within normal limits. EEG showed focal changes in 5 and diffuse slowing in onel follow-up EEG in 4 had returned to normal. No child had persistence of seizure activity after chlorambucil discontinued. Kentucky. A fonn o f familial nephritis with many features distinct: fromEven though seizure activity can not be related to age, duration of illness, sex, dosage, duration of treatment, or underlying disease, chlorambucil appears to be implicated as a contributing factor to these seizures.

An enzyme-linked immunosorbent assay (ELISA) was developed for detection of respiratory syncytial virus (RSV) in nasal secretions from infants with respiratory disease. RSV was detected in 23 of 29 secretions positive for RSV by tissue culture and in one of 36 samples negative for RSV by tissue culture. The ELISA was a simple rapid, and surprisingly sensitive test for identification of RSV infection in infants.