The human malaria parasite Plasmodium vivax is responsible for 25-40% of the ~515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated in the laboratory except in non-human primates. We determined the genome sequence of P. vivax in order to shed light on its distinctive biologic features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternate invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance scientific investigation into this neglected species.

Understanding usage patterns in wireless local-area networks (WLANs) is critical for those who develop, deploy, and manage WLAN technology, as well as those who develop systems and application software for wireless networks. This paper presents results from the largest and most comprehensive trace of network activity in a large, production wireless LAN. For eleven weeks we traced the activity of nearly two thousand users drawn from a general campus population, using a campus-wide network of 476 access points spread over 161 buildings. Our study expands on those done by Tang and Baker, with a significantly larger and broader population.We found that residential traffic dominated all other traffic, particularly in residences populated by newer students; students are increasingly choosing a wireless laptop as their primary computer. Although web protocols were the single largest component of traffic volume, network backup and file sharing contributed an unexpectedly large amount to the traffic. Although there was some roaming within a network session, we were surprised by the number of situations in which cards roamed excessively, unable to settle on one access point. Cross-subnet roams were an especial problem, because they broke IP connections, indicating the need for solutions that avoid or accommodate such roams.

Understanding usage patterns in wireless local-area networks (WLANs) is critical for those who develop, deploy, and manage WLAN technology, as well as those who develop systems and application software for wireless networks. This paper presents results from the largest and most comprehensive trace of network activity in a large, production wireless LAN. For eleven weeks we traced the activity of nearly two thousand users drawn from a general campus population, using a campus-wide network of 476 access points spread over 161 buildings at Dartmouth College. Our study expands on those done by Tang and Baker, with a significantly larger and broader population.We found that residential traffic dominated all other traffic, particularly in residences populated by newer students; students are increasingly choosing a wireless laptop as their primary computer. Although web protocols were the single largest component of traffic volume, network backup and file sharing contributed an unexpectedly large amount to the traffic. Although there was some roaming within a network session, we were surprised by the number of situations in which cards roamed excessively, unable to settle on one access point. Cross-subnet roams were an especial problem, because they broke IP connections, indicating the need for solutions that avoid or accommodate such roams.

CTCF DNA binding sites are classified into distinct functional classes, with distinct biological properties, shedding light on the differing functional roles of CTCF binding.

No abstract