Pain, weakness, and sensory loss occur frequently in the hypothenar eminence. However, clinical examination is difficult and nonspecific, and the prescribed imaging technique may be inadequate, or images may be misinterpreted. Different imaging modalities have various degrees of usefulness for the diagnosis of painful pathologic conditions of the hypothenar eminence. Radiography, multidetector computed tomography (CT), multidetector CT arthrography, and magnetic resonance (MR) imaging of the wrist are useful for surveying the anatomy of the hypothenar eminence, the Guyon canal, and the ulnar nerve and artery and for determining the cause of pain or other symptoms. A fracture of the pisiform bone or the hook of the hamate bone, osteoarthritis or osteochondromatosis of the pisotriquetral joint, Guyon canal syndrome, hypothenar hammer syndrome, tendinopathy of the flexor carpi ulnaris, an anomalous muscle, a ganglion cyst, or a tumor may be responsible for ulnar neuropathy. Specific radiographic views, such as the semisupinated oblique view and the lateral view with the hand radially deviated and the thumb abducted, often provide a sufficient basis for the diagnosis of acute fracture of the hook of the hamate or the pisiform bone. Multidetector CT angiography is an efficient method for diagnosing hypothenar hammer syndrome, and multidetector CT arthrography is well suited for evaluation of the pisotriquetral joint. MR imaging is the modality of choice for depiction of the ulnar nerve.