Purpose: The immune response within colorectal cancer is widely studied and evaluated. The presence of lymphocytic infiltration in the main mass of the tumor and its front indicates a different clinical course of the disease. The aim of the study was to presence of CD3+ T lymphocyte infiltration in the tumor and its front in correlation with clinicopathological parameters. Materials and Methods: The study included a group of patients operated on due to colorectal cancer. The histopathological results of the patients were analyzed, including the assessment of the expression of CD3 lymphocytes in the main mass of the tumor and its front, and an analysis of correlation with the patient’s age, sex, histological malignancy stage, presence of metastases to lymph nodes and distant metastases was performed. Results: We found the correlation between the differential infiltration from CD3+ T lymphocytes in the front of the invasion and the depth of tumor infiltration (p=0.008). But we do not found the correlation between the expression of CD3 in the main tumor mass and expression CD3 of the invasion front and patient’s age, sex, tumor location, histological type of the tumor, histological grade, the presence of metastases to lymph nodes and the presence of distant metastases. Conclusions: The obtained results suggest a relationship between the intensity of the CD3+ T lymphocyte infiltration in the front and the depth of the colorectal cancer infiltration.

Introduction: Colorectal cancer (CRC) is one of the most common cancers. It ranks 4th in morbidity and mortality from this cancer. The average age of onset is 55 years. Most of these tumors arise de novo in both the colon and rectum. Some cancers are associated with molecular abnormalities in the course of Lynch syndrome. Case presentation: A 17-year-old woman presented to the emergency room of the Children’s Hospital in Bialystok with symptoms of obstruction. The patient reported abdominal pain and occasional blood in the stool. Additional test showed anemia with haemoglobin 7 g/dL and Red Blood Cells count 3.0 thousand. Computed tomography and magnetic resonance imaging showed a nodular lesion in the ileocaecal valve and 3 mestastatic focus in the liver. Conclusions: Single cases of CRC in children or young adults are described in the literature. They are usually advanced tumors with poor prognosis.

Introduction: The aim of this study was to analyze the technical evaluation of cervicovaginal smears as well as the correlation of the technical quality of the smear with the patient’s age. Materials and methods: The study included a group of 43,696 women who underwent exfoliative cytology. The smears were stained according to the Papanicolaou method and then underwent cytological evaluation based on the Bethesda system. Results: The technical quality of the cytology smears was found to be satisfactory (AI) in 80.6% of cases, acceptable for cytological evaluation (AII) in 19% mainly as a result of poor readability of the smear due to numerous inflammatory cells (35.5%), whereas not suitable for evaluation (AIII) was in 0.4% of cases. Moreover, there was a high proportion of smears without cells from the cervical canal in women under 50 years of age. In women over 50, the most common cause of conditional evaluation of the smear was its excessive dryness Conclusions: In all age groups, an abundance of inflammatory cells was a factor that hindered cytologic evaluation of the smear. Only representative material containing cells from the cervical canal should be collected. It is of utmost importance to pay special attention to the correct and quick fixation of smears taken from women over 50 years of age.

The most common neck masses in adults are neoplastic in nature, so they should be treated as neoplasms until the diagnosis turns out otherwise.

The American Cancer Society recorded 9,440 new cases of rectal cancer in the US in 2022. However rectal cancer is still rarer than sigmoid cancer. The most common etiology of anal cancers are squamous cell carcinomas