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IntroductionPenile cancer is uncommon. When penile cancer is left untreated, at an advanced stage it can have tragic consequences for the patient.Case presentationOur case report does not concern a new manifestation of penile cancer, but an interesting presentation with clinical significance that emphasizes the need to diagnose and treat penile cancer early. It is an unusual case of a neglected penile cancer in a 57-year-old Greek man that led to auto-amputation of the penis and a large chasm in the lower abdominal wall. The clinical staging was T4N3M0 and our patient was treated with a bilateral cutaneous ureterostomy, chemotherapy and radiotherapy. Our patient died 18 months after his first admission in our clinic.ConclusionsEmphasis must be placed on early diagnosis and treatment of penile cancer, so further development of the disease can be prevented.