Background:In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra (Gg) (family: Leguminosae) have been studied for their ability to improve a variety of health ailments.Aims:The present study was designed to investigate the beneficial effects of Gg root extract on learning and memory in 1-month-old male Wistar albino rats. Four doses (75, 150, 225, and 300 mg/kg) of aqueous extract of root of Gg was administered orally for six successive weeks.Materials and Methods:The aqueous extracts were evaluated for their effect on spatial learning and memory in rats using the elevated plus maze, Hebb–William maze, and Morris water maze tests which served as the exteroceptive behavioral model. Diazepam-induced amnesia served as the interoceptive behavioral model.Results:Results showed that all the doses of aqueous root extract of Gg significantly enhanced the memory; however, in the doses of 150 and 225 mg/kg, it showed a significant (P < 0.01) enhancement in learning and memory. Furthermore, Diazepam-induced amnesia was reversed by the aqueous root extract of Gg (150 and 225 mg/kg, p.o.).Conclusion:These findings suggest that the memory enhancement effects of Gg may be mediated by its antioxidant and anti-inflammatory activities. Thus, Gg appears to be a promising drug for improving memory in the management of impaired learning, dementia, Alzheimer's disease, and other neurodegenerative disorders.
Knowledge of the branching pattern of the abdominal aorta is clinically important for any abdominal surgeon operating on parts of the gut or neighboring structures. Variations of these vessels may influences urological, renal transplantation and laparoscopic surgeries. We present an unreported case of multiple variations of branching pattern of abdominal aorta. It includes double renal arteries for left kidney, a common trunk with right and left phrenic, right and left superior suprarenal and left middle supra renal arteries, and a common trunk originate 2.5 cm above the bifurcation of abdominal aorta gave off inferior mesenteric, accessory renal artery to the left kidney and left testicular arteries in the middle-aged normal male cadaver. The embryogenesis of such multiple variations of branches of abdominal aorta is not clear, but the anatomic consequences may have important clinical implications. Knowledge of these variations is important for urologists, radiologists and surgeons in general.
The anatomical variations and abnormalities of the muscles of the upper limb have become significant because of new imaging techniques, such as computed tomography and magnetic resonance imaging. Among the three muscles of the anterior compartment of the arm, a very uncommon anomaly of the biceps is having three or more heads. Knowledge of the existence of the three headed or four headed biceps brachii may become significant in preoperative diagnosis and during surgery of the upper limb. The present study was undertaken to observe the anomalous origin, insertion and the incidence of three or more heads biceps brachii in the adult human cadavers. This study was carried out on 24 human cadavers at Dr. Pinnamaneni Siddhartha institute of medical sciences & research foundation (Dr. PSIMS & R.F) Gannavaram; Krishna Dist; A.P. Variant biceps brachii may cause compression of neurovascular structures because of their close relationship to brachial artery and median nerve. The surgeons and traumatologists have to keep such muscular variations in mind.
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