Mediastinal pseudocyst is an unusual and rare complication of acute and chronic pancreatitis. The symptoms are nonspecific. Imaging medical is important for diagnosis and treatment.We present a case of pancreatic mediastinal pseudocyst which is successfully treated bypercutaneous endoscopic drainage. This report is of interest because it describes a rare presentation of a pancreatic pseudo cyst (the first known case in Central Africa republic). It illustrates the range of radiological techniques in management of patients with abdominal pains.