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Cardiovascular disorders are among the critical side effects of cancer therapy. Damage to the function and normal structure of the heart can cause serious threats to patients that are being treated for cancer. Cardiovascular complications may be induced by various types of chemotherapy drugs and also radiation therapy. The severity of cardiovascular toxicity depends on several factors, such as types of drugs, tumor location for radiotherapy, the presence of cardiac disease history, the dose of drugs or ionizing radiation, etc. Radiotherapy and chemotherapy can cause heart diseases through various mechanisms, such as oxidative stress, inflammation, cell death, fibrosis, endothelial to mesenchymal transition (EndMT), etc. Chronic inflammation following damage to a huge number of cells can trigger more accumulation of inflammatory cells and chronic release of reactive oxygen species (ROS) and nitric oxide (NO). Oxidative stress can induce more cell death and cardiac remodeling through damage to vessels and valvular and disruption of the normal structure of the extracellular matrix. These changes may lead to cardiomyopathy, myocarditis, pericarditis, and vascular disorders that may lead to heart attack and death. This review provides basic information on cellular and molecular mechanisms of different types of cardiovascular disorders following cancer therapy by radiation or chemotherapy. We also recommend some adjuvants and targets to reduce the risk of heart toxicity by radiation/chemotherapy.

Over the past few years, attention to environmental problems, legal necessities, and economic advantages emerging from reproduction activities has attracted attention to reverse logistics activities in the form of a closed-loop supply chain, whether in industry or scientific research. The current study aims to model competitiveness and comparison between two closed-loop three-level supply chains, each of which includes a manufacturer, a retailer, and a third party to collect the products used by the customer, taking into account the concepts of game theory and the existence of aggregates. Moreover, a separate supplier for each chain is considered. In the forward supply chain, the manufacturer produces new products using new components or re-used products that have been collected from the consumer, then sells these products mainly to the retailer, and the retailer sells them. In the reverse chain, the collector provides the used products to the manufacturer after collection. The study utilized the definitions and concepts of game theory to model this closed loop chain as a Stackelberg game to obtain the optimal value of wholesale and retail price and the optimal value of the product return coefficient for the collector. Finally, the models based on some numerical examples are solved. Given the results, the remanufacturing costs have a significant role in making more profits for all members in such chains, and competitive chains should attempt to remanufacture the products at lower costs.

This research focuses on evaluating the impacts of technological advancements and their extended future aspects on exercising human rights in society and politics. Furthermore, the current prospects of technological advancements contribute a great portion to the advancement of society and culture. However, it also emerges and involves politics in the scenario. The research aims to explore different aspects of modern technological advancements in terms of determining the possible implementations of technology in society and politics. As a part of the research methodology, it can be highlighted that the research follows a primary research method. It collects primary quantitative data through an online survey by following a random sampling procedure. The sample population of the online survey was 50, and the ultimate sample size of this research is 39. The significance of the research lies over the identification of the technological advancements as it is the major component that impacts the future social and political community.