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The present study explores the slip flow and heat transfer induced by a radially surface with MHD Carreau nanofluid. In addition, the effects of temperature jump, non-linear radiation and the dependent zero mass flux also taken into account. This study also considers the cross-diffusion effect on temperature and concentration governing profiles. Appropriate transformations are engaged in order to acquire nonlinear differential equations (ODEs) from the partial differential system, their solutions are obtained by Runge-Kutta 4th order with shooting scheme in MATLAB. The impact of pertinent flow parameters such as first and second order velocity slip parameter, temperature jump, magnetic parameter, heat source, radiation parameter, melting surface parameter, temperature ratio parameter on dimensionless velocity, temperature and concentration profiles achieved graphically as well as local skin friction, Nusselt number and Sherwood number are demonstrated in the form of Table. first order velocity slip parameter (slip1) on f′, Θ and Φ profile fields. With an increment in the velocity slip first order parameter (slip1) we have perceived a fall in the momentum boundary layer and concentration profiles and a growth in the fluid temperature field.