Collectively, the results show that the NPEM method is suitable and relevant for large-scale epidemiological studies of population phenotyping for cancer susceptibility and for abnormal liver function by monitoring CYP1A2 activity based on sparse caffeine data.

The two studied formulations of metformin were found to be bioequivalent. They showed similar extents and rates of absorption and similar exposure. However, analysis of variance of logarithmically transformed data revealed significant variability among individuals in AUC(0-36), AUC(0-)(infinity) and C(max), making careful individualisation of the metformin dosage important.

Summary The health status of 1515 workers employed in heat production was investigated. The subjects studied were divided in four groups according to occupation and occupational risk factors: vibration, noise, dust, metal aerosols, overloading of the musculoskeletal and peripheral nervous system, and organic solvents. The control group included 152 administrative staff members. High prevalence of socially significant diseases – cardiovascular, endocrine and metabolic was detected in all the groups surveyed. The frequency of diseases of the cardiovascular system and the respiratory system was 2.7 times higher than that in the control group. Statistically reliable higher prevalence of lung diseases in the studied risk groups was found, especially in the group of welders and chemists: 45.3% и 17.4% respectively, as compared to 4.3% in the controls. These finding corresponded to the occupational risk. The following occupation diseases were diagnosed: pneumoconiosis in 26.6% and toxic pneumofibrosis in 5.1% of electric welders. As regards the group of chemists, toxic pneumofibrosis was found in 6.5%. toxic effects of irritants - in 6.5 %, and chronic intoxication with organic radicals - in 0.7 % of them. Occupational auditory neuritis was diagnosed in 1% of the turbine operators and crane operators. The relative share of workers with peripheral nervous system pathology (radiculopathies, polyneuropathies, distal sympathetic neuropathy, mononeuropathy) was reliably higher than that in the control group, and the frequency increased among the workers with more than ten years of service and older than 40.