The physiological fate of cells that die by apoptosis is their prompt and efficient removal by efferocytosis. During these processes, apoptotic cells release intracellular constituents that include purine nucleotides, lysophosphatidylcholine (LPC), and Sphingosine-1-phosphate (S1P) that induce migration and chemo-attraction of phagocytes as well as mitogens and extracellular membrane-bound vesicles that contribute to apoptosis-induced compensatory proliferation and alteration of the extracellular matrix and the vascular network. Additionally, during efferocytosis, phagocytic cells produce a number of anti-inflammatory and resolving factors, and, together with apoptotic cells, efferocytic events have a homeostatic function that regulates tissue repair. These homeostatic functions are dysregulated in cancers, where, aforementioned events, if not properly controlled, can lead to cancer progression and immune escape. Here, we summarize evidence that apoptosis and efferocytosis are exploited in cancer, as well as discuss current translation and clinical efforts to harness signals from dying cells into therapeutic strategies.

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To the Editor,The authors read with pleasure the review paper by Kim and coworkers, titled "Clinical impact of medication adherence on 10-year cardiocerebrovascular mortality in newly diagnosed hypertensive patients," that sought to assess the impact of medication adherence on cardiocerebrovascular mortality in patients with newly diagnosed hypertension. The authors concluded that medication adherence significantly improves the 10-year mortality of newly diagnosed hypertensive patients. 1 In particular, a higher medication adherence rate was associated with better outcomes in patients suffering from hypertensionrelated complications. 1 However, the following limitations should be considered when interpreting the results of this study:The researchers identified patients with hypertension based on the ICD-10 code documented in patient medical records. For patients without a medical record, the authors used the date of starting new antihypertensive drugs as an indicator of a diagnosis of hypertension. However, many antihypertensive agents, including diuretics, betablockers, and calcium channel blockers, can be used for conditions other than hypertension. For instance, beta-blockers are commonly prescribed for anxiety and migraine prophylaxis and diuretics are commonly prescribed for kidney failure and heart failure. [2][3][4][5] There-

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