The analysis and processing of ECG signals are a key approach in the diagnosis of cardiovascular diseases. The main field of work in this area is classification, which is increasingly supported by machine learning-based algorithms. In this work, a deep neural network was developed for the automatic classification of primary ECG signals. The research was carried out on the data contained in a PTB-XL database. Three neural network architectures were proposed: the first based on the convolutional network, the second on SincNet, and the third on the convolutional network, but with additional entropy-based features. The dataset was divided into training, validation, and test sets in proportions of 70%, 15%, and 15%, respectively. The studies were conducted for 2, 5, and 20 classes of disease entities. The convolutional network with entropy features obtained the best classification result. The convolutional network without entropy-based features obtained a slightly less successful result, but had the highest computational efficiency, due to the significantly lower number of neurons.

Motivation Queueing theory can be effective in simulating biochemical reactions taking place in living cells, and the paper paves a step towards development of a comprehensive model of cell metabolism. Such a model could help to accelerate and reduce costs for developing and testing investigational drugs reducing number of laboratory animals needed to evaluate drugs. Results The paper presents a Krebs cycle model based on queueing theory. The model allows for tracking of metabolites concentration changes in real time. To validate the model, a drug-induced inhibition affecting activity of enzymes involved in Krebs cycle was simulated and compared with available experimental data. Availability The source code is freely available for download at https://github.com/UTP-WTIiE/KrebsCycleUsingQueueingTheory, implemented in C# supported in Linux or MS Windows. Supplementary information Supplementary data (tables with kinetic constants, kinetic equations and pseudocode) are available at Bioinformatics online.

The electrocardiogram (ECG) is considered a fundamental of cardiology. The ECG consists of P, QRS, and T waves. Information provided from the signal based on the intervals and amplitudes of these waves is associated with various heart diseases. The first step in isolating the features of an ECG begins with the accurate detection of the R-peaks in the QRS complex. The database was based on the PTB-XL database, and the signals from Lead I–XII were analyzed. This research focuses on determining the Few-Shot Learning (FSL) applicability for ECG signal proximity-based classification. The study was conducted by training Deep Convolutional Neural Networks to recognize 2, 5, and 20 different heart disease classes. The results of the FSL network were compared with the evaluation score of the neural network performing softmax-based classification. The neural network proposed for this task interprets a set of QRS complexes extracted from ECG signals. The FSL network proved to have higher accuracy in classifying healthy/sick patients ranging from 93.2% to 89.2% than the softmax-based classification network, which achieved 90.5–89.2% accuracy. The proposed network also achieved better results in classifying five different disease classes than softmax-based counterparts with an accuracy of 80.2–77.9% as opposed to 77.1% to 75.1%. In addition, the method of R-peaks labeling and QRS complexes extraction has been implemented. This procedure converts a 12-lead signal into a set of R waves by using the detection algorithms and the k-mean algorithm.