The aim of this study was to evaluate the efficacy of tacrolimus eye drops in alleviating the clinical symptoms of canine keratoconjunctivitis sicca (KCS) and to compare this efficacy with that of cyclosporine. The clinical study was conducted on 40 dogs diagnosed with idiopathic KCS. The dogs were divided into two groups of 20 animals each. In Group I, 0.75% cyclosporine eye drops were administered three times a day, while in Group II 0.02% tacrolimus eye drops were given twice daily. In addition, each group was subdivided into three subgroups based on the results of Schirmer tear test I (STT I). Clinical and ophthalmologic examinations were performed prior to the treatment as well as after one and two months of therapy. The application of both tacrolimus and cyclosporine resulted in a significant reduction of neovascularisation after the first and second month of treatment (P < 0.05, P < 0.001); however, in moderate and advanced stages, the observed efficacy of tacrolimus was higher. Across all patients, a significant increase in STT I values was observed after both the first and second month of treatment with tacrolimus (P < 0.01), as well as after two months of treatment with cyclosporine (P < 0.05). In both groups, some patients were observed to exhibit inhibited development of pigmentation, but an analysis of particular clinical cases and statistical data revealed no statistically significant discrepancies in the course of the study. In cases of advanced canine KCS, the efficacy of tacrolimus may be higher than that of cyclosporine.

The purpose of this study was to assess the condition of cells in the conjunctiva and corneal epithelium prior to and during cyclosporine- or tacrolimusbased treatment of keratoconjunctivitis sicca (KCS). The study was performed on 40 dogs with KCS. The dogs were divided into two groups of 20 animals each. In Group I, 0.75% cyclosporine eye drops were administered three times a day, while in Group II 0.02% tacrolimus eye drops were administered twice daily. Additionally, each group was subdivided into three subgroups based on the results of the Schirmer I tear test (STT I). Evaluation of cellular metaplasia in the cornea and the palpebral and bulbar conjunctiva based on the Nelson-Adams scale was performed by impression cytology using Millipore round filters (Millipore VSWP 01300 DA) of 25 μm pore diameter applied to the studied area. Ophthalmological and cytological examinations were performed prior to the treatment as well as after one and two months of therapy. In both groups, a decrease in Nelson-Adams values was observed, corresponding to the increasing STT values [R Spearman statistically significant correlation coefficient values between -0.75 (P < 0.001) and -0.45 (P < 0.01)]. The absence of goblet cells was observed in all dogs, regardless of the KCS stage. Goblet cells reappeared following both tacrolimus- and cyclosporine-based treatment in impression cytology specimens classified as 0 in the Nelson-Adams scale. The extent of corneal and conjunctival metaplasia in the course of tacrolimus- and cyclosporine-based treatment of KCS decreases with increasing STT values.

Krótka biografia st. ułana Stefana Lipczyńskiego, wywodzącego się z osiadłej na Zamojszczyźnie rodziny ziemiańskiej, poległego w walkach na Litwie w wojnie polsko-bolszewickiej, publikowana w 100. rocznicę jego śmierci (2019), oparta o niewydane wspomnienia Grzegorza Lipczyńskiego (ojca), wspomnienia publikowane w okresie międzywojennym w „Tece Zamojskiej”, akta cywilne parafii Sitaniec i parafii Łabunie oraz inne źródła. Stefan Piotr Lipczyński urodził się w 1898 r. w ordynackim (Ordynacja Zamojska) majątku Łapiguz. W tym samym roku jego ojciec Grzegorza kupił zadłużony majątek Krynice, potem także sąsiednie Kryniczki, prowadził też interesy w Lublinie, gdzie Stefan ukończył w 1914 r. gimnazjum. Podczas I wojny Krynice stały się ofiarą grabieżczych przemarszów walczących ze sobą armii. W październiku 1918 r. Stefan, student Uniwersytetu Jagiellońskiego w Krakowie, został wysłany na zlot młodzieży w Lwowie, do którego weszły oddziały ukraińskie. Nie wziął udziału w obronie miasta, wrócił do domu, ale wkrótce wstąpił do 7 pułku ułanów (jego brat Grzegorz do baterii artylerii konnej), z nim został wysłany na front. Zginął 16 kwietnia 1919 r., w Wielki Czwartek, w szarży na bolszewików pod Lidą. Odznaczony Orderem Virtuti Militari. Rodzina sprowadziła ciało do kraju. Przytoczono akt chrztu i akt zgonu Stefana Lipczyńskiego.