Çocuklardaki göğüs ağrıları genellikle organik bir neden olmadan gelişmekte, yakınma süresi uzadıkça da neden bulma olasılığı azalmaktadır. Erişkinlerden farklı olarak kalp hastalıklarından kaynaklanan göğüs ağrıları çocuklarda ender olarak görülmektedir. Diğer yandan, göğüs ağrısına yol açabilen kalp hastalıklarının çoğunluğu hayati önemi olan, ani ölüm tehlikesi bulunan durumlardır (2). Bu nedenle çocuklarda göğüs ağrısı GİRİŞ Çocuklarda göğüs ağrısı hastanelere sık başvuru nedenlerinden biridir. Erişkinlerden farklı olarak çocukluk dönemindeki göğüs ağrılarının kardiyak kökenli olma olasılığı düşüktür. Ancak aileler tarafından ağrının kalp ağrısı olabileceğinin düşünülmesi, aileyi ve çocuğu endişelendirmekte, bu da konunun aydınlatılmasını ve ailenin bilgilendirilmesini önemli hale getirmektedir (1,2). ÖzET Amaç: Hastanemize göğüs ağrısı yakınması ile başvuran çocukların etiyolojik açıdan incelenmesi ve en sık karşılaşılan sebeplerin belirlenmesi hedeflenmiştir. Gereç ve Yöntemler: Çalışma kapsamında hastanemize Aralık 2010 ile Temmuz 2011 tarihleri arasında göğüs ağrısı yakınması ile başvuran 603 olgu geriye dönük olarak incelendi. Bulgular: Çalışma grubundaki hastaların %46.8'i kız, %53.2'si erkekti. Hastaların yaş ortalaması 11.8 ± 2.7 (5.5-18) yıldı. Hastaların %46.9'unda kas iskelet sistemi, %17.5'inde kardiyovasküler sistem, % 5.1'inde solunum sistemi, %3.3'ünde gastrointestinal sistem, %3'ünde psikojenik nedenli göğüs ağrısı tespit edildi. %21.4'ünde ise göğüs ağrısının nedeni bulunamadı ve idiyopatik göğüs ağrısı olarak değerlendirildi. Hastaların %2.8'inde göğüs ağrısının nedeni kollajen doku hastalığı, Marfan sendromu, meme büyümesi ve zona gibi diğer nedenlere bağlandı. Sonuç: Çocuklardaki göğüs ağrısının ayrıntılı araştırılması gerekliliği sonucuna varılmıştır. ABSTrAcTObjective: We aimed to examine the etiology of chest pain in children and to clarify the most common causes in this study. Material and Methods:A total of 603 patients who applied to our hospital with chest pain between December 2010 and July 2011 were retrospectively reviewed. results:The female and male percentages of the study group were 46.8% and 53.2% respectively. The mean age of the patients was 11.8 ± 2.7 (5.5-18) years. The etiology of the chest pain was related to the musculoskeletal system in 46.9%, the cardiovascular system in 17.5%, the respiratory system in 5.1%, and the gastrointestinal system in 3.3% and was psychogenic in 3%. No etiology was found in 21.4% of the patients and they were considered to be idiopathic. Other diagnoses such as connective tissue disease, Marfan syndrome, breast swelling and herpes zoster were present in 2.8% of the patients and these were classified as miscellaneous. conclusion:Chest pain in children should be investigated carefully.

Objectives Fractal analysis is a mathematical method used for the calculation of bone trabeculation and lacunarity. This study aims to evaluate the relationship between resonance frequency analysis (RFA) and fractal dimension (FD) of peri-implant bone to determine the preload stability of implants. Materials and methods In this study, the results of the fractal analysis calculated from the resonance frequency analysis results taken in the 3rd month of the patients who underwent 2-stage implant by the same doctor and the radiographs taken in the same session were evaluated. A hundred implants in 20 patients were applied in this study. The implant stability quotient (ISQ) values of the implants and fractal dimension values of the peri-implant bone were calculated. Results The findings showed that the ISQ1 ( p = 0.008), ISQ2 ( p = 0.038), ROI2 ( p = 0.013), and ROI3 ( p < 0.001) values were statistically significantly higher in men than women. The ISQ1 ( p = 0.003), ISQ2 ( p = 0.013), ROI1 ( p = 0.011), and ROI3 ( p < 0.001) of the mandible were statistically higher than the maxilla. The fractal dimension cut-off value to assess prosthetic loading was found 1.198. Conclusion Fractal analysis is a non-invasive method that can be used in conjunction with clinical examination in the prosthetic loading decision of implants. It is a valuable parameter that can be used without the need for an extra device when it is necessary to reduce the clinical study time. Clinical relevance Calculating the fractal dimension of the peri-implant bone is a practical, economical, and applicable method for clinicians. FD calculated from panoramic radiographs used for diagnosis in routine treatments in clinics where access to the necessary devices for ISQ measurement is not available will contribute to clinical practice. Supplementary Information The online version contains supplementary material available at 10.1007/s00784-022-04464-3.

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ObjectivePaeoniflorin (Pae) is a monoterpene glycoside with immune‐regulatory effects. Several studies have already demonstrated the impact of Pae on periodontitis, but its effect on diabetic periodontitis is unclear. In this study, our aim was to test the hypothesis that Pae had a strong anti‐inflammatory effect that prevented bone loss in diabetic periodontitis.MethodsThirty male Wistar albino rats were randomly divided into control (healthy, n = 10), periodontitis (PD) + diabetes (DM; n = 10), and PD + DM + Pae (n = 10) groups. Ligature‐induced periodontitis was created by placing 4–0 silk ligatures around the lower first molars on both sides of the mandibulae. Experimental DM was created via an injection of 50 mg/kg and streptozotocin (STZ). Hyperglycemia was confirmed by the blood glucose levels of rats (>300 mg/dL). The bone mineral density (BMD), trabecular number, trabecular thickness, and bone loss were measured by micro‐CT. The expression levels of IL‐1β, IL‐6, and TNF‐α were measured in tissue homogenates by ELISA.ResultsThe PD + DM + Pae group had significantly less alveolar crest resorption when compared to the PD + DM group. There was also a significant difference between the PD + DM + Pae group compared to PD + DM group in trabecular thickness, BMD, and the number of trabeculae. Pae application led to a statistically significant decrease in IL‐1β, IL‐6, and TNF‐α levels in diabetic periodontitis.ConclusionSystemic application of Pae suppressed inflammation caused by PD and DM, leading to reduced bone loss and enhanced bone quality.

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