New drugs introduced on the market each year have privileged structures specifically for anticancer targets, of which quinoline-based analogues also play an important role. This review lit up quinoline and its derivatives, which have great potency against various cancer cells including prostate cancer, breast cancer, colon cancer, pancreas cancer and many more. This review describes the most likely process-scale synthetic approaches of quinoline and its derivatives having specific pharmacophore, for anticancer targets along. It is also described the undergoing development and recently approved drugs in tabular form. Quinoline moiety as privileged structural pharmacophore has most effective activity against different cancer cell lines like prostate cancer, breast cancer, stomach cancer, pancreas cancer, Colon cancer, CNS cancer and renal cancer. Because of this advantage, it has the potency to grow with new research works about the anticancer as well as enhancing the value of the investigative process in the field of medicinal chemistry by introducing new effective alignments of substituents. It can be used as lead compounds for further research in the subject of anticancer drug discovery.

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: Diabetes mellitus refers to one of the leading cause of diseases that affect large populations of human and is characterized by a high glucose level in the blood (also known as hyperglycemia). Thiazolidinedione (TZD) is a five-member heterocyclic compound consisting of three carbons, nitrogen and sulfur. It is also known as glitazones, can be used as potent hypoglycemic agents and is also reduce many other cardiovascular risk factors including percutaneous coronary intervention, carotid and coronary atherosclerosis. As it plays a very important role in the field of medicinal chemistry or pharmaceutical sciences, novel medicine developed and many are on underdevelopment, these derivatives have thiazolidinedione as their primary nucleus. This article has discussed the different synthetic procedures of thiazolidinediones that exhibited potential antidiabetic activity by the activation of PPAR-γ, by reducing the blood glucose levels and by different metabolic process incorporation. Thiazolidinediones has an effective profile as the future investigational drug and can be processed in drug discovery because of its efficient anti-diabetic potential.

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