In the modern era of drug delivery, microsponges have their own tremendous properties of porous nature, due to this porous nature they have a capacity to entrap active drug and acts as a drug carrier because of this entrapment controlling the drug release and targeting the drug to a particular site is possible. Initially, this microsponge drug delivery has been used for topical route and later on oral route, recently, researches focused on the pulmonary and parenteral route of delivery. The present review aims at the development of microsponge technology in oral drug delivery, preparation, formulation considerations, characterization, recent advancements, and future prospects of microsponge drug delivery.

Objective: The current study was based on the many different dose frequencies of entacapone, an anti-Parkinson's drug that was loaded with microsponges to change the dose frequency of the drug administration. Methods: Microsponges were made utilizing polymethacrylate polymers such as eudragit L100, eudragit S 100, and eudragit RS 100 in various ratios using a quasi-emulsion solvent diffusion, ratios such as (1:0.5, 1:1, 1:1.5 and 1:2). These polymers release the drug in a controlled manner. The polymer used for the preparation of microsponges was useful in forming sponges in which the drug was entrapped. By using the 3 polymers,12 formulations were prepared. Results: FT-IR and DSC tests were carried out and it was clear from the FT-IR and DSC spectra that there were no interactions between the entacapone and the polymer. out of 12 formulations 3 formulations were selected as optimized formulations based on the production yield (%), encapsulating efficiency, drug loading (%), and SEM analysis says that the produced microsponges formulation was extremely porous, indicating their potential for increased drug loading.