The taxonomicalJ characters of 208 strains of glutamic acid-producing bacteria and the bas cTlpositions of DNA solated from representative strains were studied.Then organisms are, in general, Gram-positive, non-sporulating, nonmotile, ellipsoidal spheros to short rods, pleomorphic and require biotin for growth and acc ~im~ date aerobically large amounts of L-glutamic acid.

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A culture of Micromonospora species MK-70 was found to produce two new antibiotics, fortimicins A and B. Antibacterial and paper chromatographic data on an eluate from IRC-50 treatment of fermentation beers indicated that fortimicins A and B are new antibiotics with broad-spectrum, basic and water-soluble properties. Fortimicin A exhibited potent, unique, broad-spectrum antibacterial activity against Gram-positive and negative bacteria both in vitro and in vivo, while fortimicin B was only weakly active.In the course of screening for new antibiotics, a complex of antibacterial antibiotics was obtained from the culture broth of Micromonospora sp. MK-70. This antibiotic complex XK-70 contained two main components designated as XK-70-1 and XK-70-A, both of which exhibited broad-spectrum antibacterial activities. Subsequent studies showed that the two antibiotics are new aminoglycosides, as reported both in the present report and in other papers describing isolation, characterization and structure determination1,2). Therefore we designated XK-70-1 and XK-70-A as fortimicin A and fortimicin B, respectively. This paper deals with the producing organism, fermentation and the biological properties of fortimicins A and B.

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