Coronavirus disease 2019 (COVID‐19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The spectrum of symptomatic infection ranges from mild to critical with multiple severe complications. Many vaccines have been developed to prevent COVID‐19 disease, including an mRNA vaccine. Different adverse effects were reported as delayed large local reactions, swelling, erythema, urticarial, and morbilliform rashes. Among these, bullous reactions from the vaccine are considered rare. Here, we described a local bullous reaction after an mRNA booster vaccination in a post‐COVID patient.

COVID-19 is a worldwide pandemic disease that caused respiratory symptoms and severe complications. The mRNA vaccine were developed to prevent COVID-19 disease. Here we reported a case of a subepidermal blistering eruption as a cutaneous reaction after mRNA boosted vaccination in a post-covid patient.