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Treatment with itraconazol (400 mg once a week) was added for onycomicosis. Two weeks later, the patient was discharged from the hospital with substantial improvement of oedema and erythema, healing of the ulcers and pain relief.This patient represents a typical case of primary erytromelalgia. Diagnosis of this condition is important because proper counselling can enable the patient to minimize the severity and frequency of the painful episodes. Davis et al. in a retrospective review of 168 patients with erythromelalgia showed increased mortality in patients with erythromelalgia compared with matched control subject. 5 Erythromelalgia decreases quality of life and makes normal social function, work and family life impossible. There is no effective therapy for erythromelalgia. Most available clinical evidence regarding treatment of erythromelalgia comes from anecdotal studies. Treatment options include sodium channel blockers, intravenous lidocaine, prostaglandin analogs, serotonin reuptake inhibitors, venlafaxin, 6 opiods, mexiletine, gabapentin and betaadrenergic drugs; however, further research is needed to develop more effective treatments. 7

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Apocrine nevi are benign adnexal cutaneous hamartomas characterized by localized hyperplasia of mature apocrine sweat glands (ASG). Although ASG proliferation can be found in a number of acquired or congenital adnexal skin tumors, pure apocrine nevi are exceedingly rare. We present herein a new typical case of this tumor that was studied immunohistochemically, and review the relevant literature in order to delineate its clinicopathological features.

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