With the advent of the Fourth Industrial Revolution, the Korean industrial environment has been rapidly changing. As a result, several industries are facing different innovation conditions, including: the automotive industry, which is a traditional manufacturing industry in Korea; the aerospace industry, which has been vertically integrated, and has been led by a single large company-Korea Aerospace Industries-since Korea went through an economic crisis in the 1990s; and the robotics industry, which is currently emerging. This study used parameters related to patents originating from the automobile, robotics, and aerospace fields. The patents subjected to analysis were those registered in Korea from 2001 to 2014, and included those that were applied for, jointly applied for, or registered by Korean companies. This study analyzed the differences caused by the effect of open innovation in the three industries. According to our results, first, the three industries experienced different effects of open innovation. Second, when large companies controlled a given industry, open innovation either worked a little or did not work at all. According to this research result, the Korean robotics industry, which has a weak dominance of large companies, experienced a strong effect of open innovation, in that joint patent applications led to economic gains from the patents and an increase in technology transfer and technology value. The aerospace industry of Korea, which has the highest dominance of large companies, experienced a slight effect of open innovation, as the effect of joint patent application only improved the technology value. Finally, the automotive industry of Korea had an intermediate level of open innovation, between the aerospace and robotics sectors.

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This study verified that progressive bodyweight-supported treadmill training had a positive influence on the temporospatial characteristics of gait and clinical gait evaluation index in chronic stroke patients.

Background: Novel three-layered (TL) tablet systems were compared with both monolithic matrix (MM) formulations and a commercial immediate-release (IR) capsule to develop once-a-day (OAD) pregabalin tablets. Methods: The physical properties of the TL tablets, including dissolution and swelling rates, were compared with those of the MM tablets and the pharmacokinetic parameters of the TL tablet were compared with those of an IR capsule in beagles and humans. Results: Our results indicated that the same amount of a hydrophilic polymer in the formulations had similar dissolution profiles at 12 h, regardless of the tablet geometry. However, the degree of tablet swelling differed, with larger amounts of polymer in the tablets showing a greater degree of swelling. In addition, TL tablets swelled more rapidly compared with MM tablets. For the pharmacokinetic study of the TL tablet, the beagles demonstrated absorption results similar to those of an IR capsule, whereas the humans demonstrated low total absorption compared with an IR capsule. The time of the peak plasma concentration at 6 h in the fed state of humans coincided with the results of the study on beagles. Conclusion: The novel TL tablet system of pregabalin may prove to be helpful in developing improved formulations with better continuous drug absorption for OAD administration.

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