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Six discrete protease activities were recovered from the supernatant broth of Legionella pneumophila cultures by ion-exchange chromatography. One of these demonstrated in vitro activity against collagen, casein and gelatin. When administered into the lungs of guinea-pigs this protease elicited lesions which were pathologically similar to those seen in clinical and experimentally induced Legionnaires' disease.

The molar ratios of sterol to phospholipid in plasma membranes of five different types of rat cells range from 0.24 to 1.32. The composition of the plasma membrane of a cell has no fixed relation to that of the mitochondria. Thus the structure of cellular membranes shows both tissue and functional specificity.