According to the available literature sources, the prevalence of diabetes in Ukraine is increasing every year which is related to the peculiarities of the age structure of the population, urbanization, dietary changes and sedentary lifestyle. More than 90% of the incidence is type 2 diabetes. Metformin is the most common oral antihyperglycemic drug in Ukraine. Among the most significant side effects of long-term metformin administration is the development of B12-deficiency anemia, which can lead to neuropathy, which is sometimes misdiagnosed as diabetic neuropathy and, accordingly, is improperly treated. This leads to the progression of irreversible changes in nerve fibers. At the same time, existing violations could be easily corrected in the early stages. [1] Aim. To investigate homocysteine and vitamin B12 levels in patients that receive metformin as monotherapy for a long time. Materials and Methods. A retrospective analysis of case histories of 40 patients with type 2 diabetes aged 45-60 years with a history of diabetes of at least 5 years was carried out. Group 1 included 25 patients who received regular metformin as monotherapy at a dose of 2 g per day for 5 years, group 2 included 15 patients who received drugs from the incretin group during the same period of time. Results. The analysis showed that the use of metformin in patients with diabetes was associated with decreased serum B12 concentrations compared to the group of type 2 diabetes patients who did not take metformin (lower than 150

people)an increased level (18-21 points), 27% (8 people) with a high level (22-25 points) and 10% (3 people) with a very high level (26-28 points). As shown by the results of the survey on a scale for assessing the impact of a traumatic event, 20% of respondents (6 people) were dominated by symptoms of avoidance, 27% (8 people) invasion, and 53% (16 people) symptoms of arousal. Conclusions: the combat experience of most patients who were in the zone of Operation of the incomporated forces are in the range from medium to high. Only 10% received a very high level influence of combat trauma. The length of time spent by respondents in the combat zone ranged from 60 to 340 days. Avoidance symptoms prevailed in 20% of respondents (6), intrusion symptoms prevailed in 27% (8), and arousal symptoms in 53% (16). Therefore, in the future, it is in this direction that the target of psychotherapeutic and psycho-educational programs in this category of patients will be considered.

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