Since the chronic endometritis often leads to impaired reproductive function causing infertility, failed IVF attempts, miscarriage, and complicated pregnancy and childbirth, it has become not only medically relevant but also socially significant. For successful embryo implantation, the thickness of the endometrium should be at least 7 cm. Even though there is always a chance for embryo implantation, despite the endometrial hypoplasia, the attachment may be fragile, and such pregnancy may cease its development further on. Recently, in connection with an increase in the rate of developing allergic reactions, dysbacteriosis, and the emergence of drug-resistant strains of microorganisms, a search for new treatment methods to avoid these complications has begun. One of such methods in treating chronic endometritis, satisfying several requirements (efficiency, comfort, accessibility, safety), is the ultrasonic cavitation of the uterine cavity.

In this review, conducted according to world literature, we sought to determine the role of mitochondrial DNA (mtDNA) in the formation of mitochondrial diseases. To determine the availability of treatment methods for hereditary diseases, in particular those associated with mitochondrial diseases, and to assess the role of mitochondrial replacement therapy (MRT) in assisted reproductive technologies. The scientific articles corresponding to the chosen goal are published on MEDLINE, EMBASE, in the Cochrane Library, PubMed, and other information sources. The search strategy combined the following search terms “mitochondrial diseases,” “mitochondrial replacement therapy,” “three-parent baby,” “ART,” “genetic engineering”.

This world literature review tries to determine the significance of the gamete donation in the field of assisted reproductive technologies as well as the availability of treatment methods using donation in in vitro fertilization programs. Gamete donation is regulated by every country's national legislation system, and quite often the laws vary between the states. There are practically no universal standards and/or rules in this area, which, in turn, leads to an ambivalent reaction towards reproductive practices.

Background: A number of important problems remain unresolved in the field of assisted reproductive technologies (ART) using germ cells from a single donor. This study aimed to assess attitudes about the use of sex gamete donation in ART in different social groups including medical workers, oocyte recipients, and oocyte donors. Methods: To achieve this goal, we surveyed 286 participants from seven countries. Of them, 190 were medical workers from ART clinics (respondents from seven countries), 45 were oocyte recipients (Kazakhstan), and 51 were oocyte donors (Kazakhstan). Results: A survey of the three groups showed that issues related to donor health were most common in the donor selection process based on patient and doctor distrust of the health care system. The main motive for oocyte donation was financial compensation, which draws attention to the social disadvantage of the donor population. Medical workers with more than 5 years of work experience (79.7%) supported the use of programs tracking donor sex gametes and limiting the use of oocyte donors. Conclusions: The willingness and consent of the surveyed medical workers and oocyte recipients to use the donor material and create a unified registry of donor sex gametes demonstrates the importance of this issue.

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