Цель работы-изучить состояние сердечно-сосудистой системы у детей школьного возраста в зависимости от уровня контроля бронхиальной астмы.

The work is devoted to the study the specific characteristics of mental status in patients with different variants of polymorphic regions of the A1438-G gene of the serotonin receptor 2A (HTR2A), ill with rheumatoid arthritis, depending on gender, and to study the relationship between anxiety-depressive disorders and pain intensity and clinical signs of the disease. Materials and мethods used in the study. The distribution of genotype rate of serotonin receptor 5-HT2A A1438-G gene was studied in 100 patients with RA. Anxiety level was assessed by Spielberger State-Trait Anxiety Scale. Depressive status and depression severity was evaluated by Hamilton Depression Rating Scale. Females with GG genotype were found to have higher level of pain feelings and the presence of anxiety signs associated with depression symptoms, while in males with GG genotype had the prevalence of inflammatory component and the depression symptoms.In females with AA genotype pain syndrome indices were associated with high anxiety indices, and in females with AG genotype they were dependent on the presence or absence of anxiety and depression, while in males with AG genotype pain syndrome was associated with SA indices.

The aim of the study: to assess supplementary feeding in breastfed neonate, evaluate infant and maternal indications for supplementation in healthy infants. Methods. An anonymous voluntary survey about supplementary feeding of 50 women who has breastfed children and visited the hospital for various reasons, not related to breastfeeding. According to the results of survey, the main reason for starting supplementary feeding was the insufficient amount of breast milk in the mother (63,20%). Other reasons included: low body weight of the child, illness of the mother, difficulties in applying to the breast, restlessness of the child. After the introduction of supplementary food, only 3,80% of children were returned to exclusively breastfeeding, 22,20% - remained on mixed feeding until the introduction of complementary food, and 29,60% had artificial feeding. The majority of women (74,10%) did not use any methods to improve lactation. Half of the surveyed mothers (56,00%) who introduced supplementary feeding gave milk formula to feed their child and used bottle feeding (32,60%) and spoon feeding (21,30%). Conclusions: the majority of interviewed women had a shortage of breast milk, which was the main reason for the introduction of supplementary food; the best supplementary food product is mother's or donor's milk; a third part of the surveyed women used bottle feeding; the decision to introduce supplementary food should be made by the doctor individually to every child.

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Objective-to study the indices of general and specific quality of life in schoolchildren, depending on the level of bronchial asthma control. Materials and methods. Quality of life parameters of 189 in-patients with BA, aged 6-17 years and 95 controls were studied. Parallel questioning with subsequent analysis of quality of life indices in 189 parents of BA children and 95 parents of the control group children was performed. General QL was evaluated using РedsQL (Pediatric Quality of Life Inventory 4.0). Specific quality of life was evaluated using specific quality of life questionnaire for the children ill with bronchial asthma-PAQLQ (Pediatric Asthma Quality of Life Questionnaire). Statistical analysis of the data obtained was done by variance statistical methods using the standard program package of multivariate statistical analysis Statistica 6.0 Results. The study found the index of physical functioning to be 43.6 [31.3-62.5] points in the children with UC BA, 53.1 [37.5-68.2] points in those with PC BA, being significantly lower as compared to the control group children-79.6 [56.0-100.0] points (P < 0.001). Рhysical functioning index in the children with UC BA was 1.7 times lower as compared to those with C BA. Comparison of the indices in those with PC BA-53,1 [37.5-68.2] points and C BA-74.1 [50.0-76.0] points, showed that physical activity in the children with PC BA was significantly lower as compared to those with C BA (P < 0.001). The analysis showed no significant difference between the answers of the children with asthma and their parents. No significant difference between the answers of healthy children's parents and the children themselves was revealed as well (P > 0.05). The cumulative index of QL was dependent on the level of BA control. It was 2.5 [1.4-3.6] points in the children with UC BA, being significantly lower as compared to those with PC BA-3.9 [2.8-4.9] points, and C BA-6.2 [5.6-6.8] points (P < 0.001); and in the children with PC BA this index was significantly lower as compared to those with C BA (P < 0.01). Conclusions. Along with traditional methods of assessment of respiratory function and laboratory indices of inflammatory process activity in bronchial asthma, study of physical and mental health, social activity, general wellbeing and many other parameters of quality of life, as well as the influence of treatment on these parameters should be carried out.