This paper provides a preliminary inventory of the Lepidoptera from the Sempre Vivas National Park, a mountain area (1200 to 1400 m a.s.l.) that combines savannas (Cerrado) and open rocky montane fields (campos rupestres) in the north-central region of Minas Gerais, Brazil. Collections were made by active search using nets and Van Someren-Rydon bait traps in two periods: one from 2010 to 2011 (10 sampling days) and the other from 2018 to 2019 (20 sampling days). A total of 1181 individuals of 238 species were sampled, distributed in 18 subfamilies of six Lepidoptera families. Noteworthy were the records of Rhetus belphegor (Westwood, [1851) (Riodinidae), Magnastigma julia (Lycaenidae), and Strymon ohausi (Spitz, 1933) (Lycaenidae), species included in the BrazilianRed List of threatened Lepidoptera. Five species endemic to the Cerrado biome were reported, namely Cogia cerradicola (Mielke, 1967) (Hesperiidae), Parides bunichus diodorus (Hopffer, 1866) (Papilionidae), Nhambikuara cerradensis Freitas, Barbosa & Zacca, 2018, Yphthimoides cipoensis Freitas, 2004 (Nymphalidae), and Sertania jaibensis (Callagham & Soares, 2001) (Riodinidae). Although preliminary, the information presented here is important for the management of the Sempre Vivas National Park and contributes to a crucial body of data to support actions for the conservation of the Cerrado biome in Brazil.