ABSTRACT.Janssen TWJ, van Oers CAJM, van Kamp GJ, TenVoorde BJ, van der Woude LHV, Hollander AP. Coronary heart disease risk indicators, aerobic power, and physical activity in men with spinal cord injuries. Arch Phys Med Rehabil 1997;78:697-705. Objective: To compare the lipid and (apo-)lipoprotein profile and blood pressure of men with long-standing spinal cord injuries (SCI) to those of an age-matched able-bodied (AB) population, and to assess the most important determinants of this profile and blood pressure.Design: A cross-sectional study of persons with chronic SC1 residing in the community.Setting: Tests were performed in a university research laboratory.Subjects: Thirty-seven men (age 37.4 2 12.0yrs) with longstanding (14.7 + 8.6yrs) SC1 ranging from level C4/5 to L5 volunteered to participate. Comparisons were made with published data from 3,498 AB men, age 20 to 59yrs, from the same country. Results: None of the lipid variables were related to the lesion level. TC, HDL-C, and TC/HDL-C were not significantly different from the AB population. The most important determinants of TC, LDL-C, and the ratios TCEIDL and HDL-C/LDL-C were age, smoking behavior, and activity level. Aerobic power was not an important determinant of any lipid or (apo-)lipoprotein or blood pressure.Conclusion: Men with long-standing SC1 do not appear to have an essentially different coronary heart disease risk profile compared with AB persons. Modifiable risk factors such as activity level, smoking, alcohol consumption, body mass index, and adipose tissue were more important than lesion level and aerobic power in the determination of the lipid and lipoprotein profile, suggesting several potential interventions. No commercial party having a direct or indirect interest in the subject matter of this article has or will confer a benefit upon the authors or upon any organization with which the authors are associated.Dr I NDIVIDUALS WITH spinal cord injuries (SCI) are at increased risk of coronary heart disease (CHD).' CHD is one of the most important causes of death in persons with SCL2 occurring at younger ages than in the able-bodied (AB) population. Some of the most important indicators of an increased risk are high serum concentrations of total cholesterol (TC) and low concentrations of high-density lipoprotein cholesterol (HDL-C).3 HDL-C levels have been reported to be significantly lower among persons with SC1 than in the AB population.4-9 In contrast, Cardus et al" did not find significant differences in total cholesterol (TC), HDL-C, and low-density lipoprotein cholesterol (LDL-C) between men with SC1 and age-matched AB men.It has been suggested that the lower HDL-C levels are due to an inactive lifestyle and a concomitant reduction of cardiopulmonary fitness of persons with SCI.7 In AB individuals an inverse relation has been reported between aerobic power, the most common measure of cardiopulmonary fitness, and TC, LDL-C, triglycerides (TG), and a direct relation between aerobic power and HDL-C, apolipoprotein A-l (apoA-1), ...