Background: Hepatic Encephalopathy (HE) is life-threatening complication of liver disease occurs with liver failure and may result from the accumulation of ammonia and other toxic metabolites in the blood. Aim of the study: Was to evaluate the impact of educational program for hepatic encephalopathy on nurse's performance and patient's outcomes. Research design: A quasi-experimental research design will be utilized. Sample: All the available nurses (40) who are caring for patients with hepatic encephalopathy regardless of their age and years of experience. Sample sizes of at least 50 patients with hepatic encephalopathy. The study was conducted at Intensive Care Units at Benha University Hospital. Tools were obtained through three main tools; Structured Interview Questionnaire Sheet, Nurse's Observational Checklist for hepatic encephalopathy care and Patient's Outcomes Sheet. Results: There is a highly statistically significant difference between knowledge and practice of studied subjects pre, immediate after implementation and 3 month post implementation of designed hepatic encephalopathy program (P < 0.000**). There was a highly statistically significant difference between nurse's performance and patient outcome of designed hepatic encephalopathy program. Recommendation: Educational programs for nurses in ICU should be continuous for improve nurse's level.

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