Glycine plays an essential role in human metabolism and nutrition; it is an integral component of many organismal elements, which is an opportunity for the widespread use of this amino acid in various pathologies. The purpose of the review is to combine the available data on the efficacy of glycine therapy in various pathologies. Materials and methods. We identified potentially relevant studies by searching the electronic databases MEDLINE, SCOPUS, PubMed, Google Scholar, and the Cochrane Database of Sys tematic Reviews over the last decade up to November 2022 using the terms: glycine, aminoacetic acid, therapy, stroke, stress, chronic stress, oxidative stress, cerebrovascular accidents, alcoholism. Further, ac cording to the inclusion and exclusion criteria, as well as by means of independent selection, all the authors of this article selected sources that met the criteria and compiled this review. Results. To date, there are quite a few studies on the use of glycine in various pathologies, however, the available data allow making a conclusion about prospective viability of using glycine in chronic stress, various cognitive impairments, ADHD therapy, chronic alcoholism, post-COVID syndrome, and diseases associated with viral agents.