Nowadays there is a tendency towards the spread of viral diseases that cause significant complications to human health. Therefore, the question of creating new drugs that have a high antiviral effect is topical. The aim. To study the range of drugs in Ukraine for the treatment of herpes viral diseases. Materials and methods. In the work were used the list of drugs from official sources of information, which were processed by methods of generalization, systematization, graphic, comparative and structural analysis. Results and discussion. The marketing research of drugs for the treatment of herpes viral diseases presented at the pharmaceutical market of Ukraine has been conducted. According to the results it is found that 80 drugs for the treatment of herpes viral diseases of various dosage forms are presented in the domestic market, of which 70 % – tablets; 51 % – medicines produced by the industry of Ukraine; 94 % – are monocomponent preparations. Soft drugs play important role in the treatment of skin diseases because they provide a direct effect of the drugs on the pathogens, eliminate inflammatory phenomena and eliminate or reduce the symptoms of the disease. Soft dosage drugs have practically no contraindications, they can be used at any age, regardless of the presence of comorbidities. Conclusions. Domestic drugs (51 % of the total range) dominate in the market structure. The main part (94 %) consist of monocomponent preparations. The results of the research prove the relevance of the development of new combined soft dosage forms for the treatment of herpes viral diseases, which should be produced by the Ukrainian industry and satisfy the medical and economical needs of patients. The results of the marketing analysis show that it is relevant and promising to create new combined the soft dosage forms for the treatment of herpes viral diseases.

Pork production plays a significant role in meat balance of Ukraine. High productivity of pigs is accompanied with increased intensity of metabolic processes and intense functional activity of all organs and systems, which requires additional support. To grow a healthy livestock, it is necessary to use preparations and biologically active forage plant additives that help a body to realize productive qualities, fight against various pathogens, but do not harm the animal body and are safe in the production of meat products for human nutrition. The influence of phytobiotic of the cardiac macleaya (Macleáya cordáta R. Br.) has been investigated separately and in combination with vegetable additives (buckwheat, ground onion and buckwheat husks) as a source of flavonoids on the physiological state and carbohydrate metabolism of pigs. It has been determined that application of only macleaya supplements to the 30 and 60 days of studies leads to an increase in the number of erythrocytes by 16.7% and 23.2% (P < 0.05) and hemoglobin concentration by 30.7% and 37.9% (P < 0.01), as well as activation of anaerobic glycolysis, as evidenced by a significant increase in glucose concentration by 96.4–48.0% (P < 0.01), lactate by 71.4–55.2%, (P < 0.01) and activity of lactate dehydrogenase at 18.6–29.4% (P < 0.05) and reduction of pyruvate content by 34.0–13.4% (P < 0.01) and activity of alkaline phosphatase – by 66.2% and 76.8% (P < 0.01) in the corresponding terms of research. While using macleaya with green buckwheat, buckwheat and onion husks, the hematological parameters and parameters of carbohydrate metabolism were at the level of the control group, confirming the significant decrease in the concentration of glucose and lactate compared with the control and shift ratio lactate / pyruvate towards pyruvate. This fact suggests that bioflavonoids, which are part of plant additives, have not only antioxidant properties, but also serve as a correction and stabilizer of carbohydrate metabolism and mitigate the side hypoxic effects of alkaloids of phytobiotic of the macleaya cordata.

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Liver damage is a common problem all over the world. To optimize the drug provision in the limited financing of the Health Care System, it is necessary to develop new drugs with hepatoprotective properties that are highly effective and of low cost. That is why we developed the original drug Lavaflam. Lavaflam is a combination of the following substances: dry concentrate of Helichrysum arenarium and Lavender oil. The purpose of the research was to assess the biochemical evidence of the hepatoprotective properties of the drug Lavaflam on the experimental model of subchronic hepatitis in rats. Construction of an experimental model of subchronic hepatitis in rats, comparison of hepatoprotective properties of Lavaflam and Carsil preparations on the basis of biochemical research. The subject of the study was to determine the hepatoprotective properties of Lavaflam tablets. Experimental subchronic hepatitis induced in rats by way of intragastrical introduction of tetrachlormethane. The study drug Lavaflam in this experimental model of subchronic tetrachlormethane hepatitis in rats showed a positive effect on oxidant processes by increasing the compensatory mechanisms of antioxidant systems; inhibiting free radical pathology; having positive effect on the processes of biliary excretion, cholestasis, reduction of infiltrative, destructive and inflammatory process in the liver; decreasing the cytolytic process; restoring the structure of the membrane components of hepatocytes; stabilizing and enhancing functional activity of the liver; restoring its protein-synthetic function; and increasing the ability of the drug Lavaflam to restore metabolic and liver damage.As a result of the performed biochemical study of the hepatoprotective action of Lavaflam, it has been found that in the developed drug Lavaflam, the level of hepatoprotective action corresponds with the reference drug Carsil.

Aim. Substantiate the methodology of creating the soft dosage form for the treatment of herpes viral diseases, taking into account the existing requirements for pharmaceutical drug development. Materials and methods. Drug creating is possible only with a theoretically and experimentally justified process of planning experimental research. To ensure the effectiveness and minimize side effects of the drug under development, it is necessary to take into account all pharmaceutical factors that have affect on the quality of the drug. These are the nature and quantity of the base, physical and chemical properties of active and auxiliary substances, structural and mechanical characteristics and equipment. The methodological concept of antiviral drug development is based on the implementation of complexes of marketing, pharmaco-technological, physico-chemical and biopharmaceutical research, which ensures compliance of the drug with medical and biological requirements. Results. It was found that the general algorithm of the methodological approach consists of 3 consecutive stages: information retrieval, research and standardization-pharmacological. Based on the analysis of literature sources and own research, a plan for creating of the soft dosage form with the antiviral effect based on acyclovir and miramistin was developed. Conclusions. The main methodological aspects of creating the soft dosage form with antiherpetic action, taking into account the requirements for the quality of the drug are shown. Key words: methodology; drug; research algorithm; soft dosage form