After HLA-identical transplantation of bone marrow to two patients with leukemia with erythrocytic phenotype B (III) Rh+ and A (II) Rh+ from two donor sibs with opposite blood groups A (II) Rh-and B (III) Rh+, 10-15% erythrocytes of phenotype AB were produced for several months in both recipients, which may be due to the formation of hybrid hemopoietic cells.
HLA levels were estimated in the plasma of allogeneic bone marrow recipients with and without graft-versus-host disease (GVHD). It was found that the level of plasma-soluble HLA is elevated in recipients with developing acute GVHD and that a rise in these antigens coincides with the onset of clinically manifest GVHD.
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