Objective. To determine the role of placental growth factor, fibronectin, certain hemostatic parameters and glycodelin in the genesis of early miscarriage.Materials and methods. Venous blood, inpatient medical records (form No.003/u-07), prenatal records (form No.113/u-07) of 94 pregnant women. The software package "Statistica" 10.0 and the programming language "R" version 4.1 were used for statistical analysis.Results. Placental growth factor, fibronectin and glycodelin can be considered as laboratory markers of miscarriage during the first trimester of gestation.Conclusion. The markers of early reproductive losses we have identified underlie the development of endothelial and hemostasiological disorders and morphofunctional inferiority of the endometrium.

Background. The unexpected emergence and rapid spread around the world of a new coronavirus infection COVID-19, with a large number of deaths, has shown the importance of developing the methods for predicting a severe course of viral infections, creating diagnostic tests, preventive vaccines and drugs that act on key factors in the course and progression of the disease. Clinical studies examining metabolomic changes in pregnant women with COVID-19 infection are virtually non-existent. Purpose of the study. To study the features of the metabolic profile of free amino acids during pregnancy complicated by COVID-19. Material and methods. The concentrations of free amino acids and their derivatives in the blood plasma of 86 women were studied. The main group included 51 pregnant women with a confirmed diagnosis of COVID-19; the control group was composed of 35 somatically healthy women with uncomplicated pregnancies. The analysis of amino acids and their derivatives was carried out using high performance liquid chromatography. Results. During the development of COVID-19 infection, protein catabolism predominates, as evidenced by an increase in the concentration of 28 amino acids and their derivatives in venous blood plasma. We revealed a statistically significant increase in the concentration of cysteine, homocysteine, γ-glutamylcysteine, phosphoserine, cysteine sulfinate, aspartate, homocysteate, glutamate, asparagine, serine, threonine, 1-methylhistidine, glycine, citrulline, arginine, alanine, symmetric dimethylarginine, asymmetric dimethylarginine, β-aminobutyric acid, γ-aminobutyric acid, tyrosine, valine, methionine, phenylalanine, leucine, isoleucine, lysine, ornithine in pregnant women with a new coronavirus infection as compared to the patients in the control group. Conclusion. The study of the features of the metabolic profile of free amino acids in pregnant women with a new coronavirus infection will enable us to identify additional biomarkers of the severity of the disease and predict the course of the disease in patients during the gestation period.