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The onset of a neurological disorder, such as amyotrophic lateral sclerosis (ALS), is so subtle that the symptoms are often overlooked, thereby ruling out the option of early detection of the abnormality. In the case of ALS, over 75% of the affected individuals often experience awkwardness when using their limbs, which alters their gait, i.e. stride and swing intervals. The aim of this work is to suitably represent the non-stationary characteristics of gait (fluctuations in stride and swing intervals) in order to facilitate discrimination between normal and ALS subjects. We define a simple-yet-representative feature vector space by exploiting the ambiguity domain (AD) to achieve efficient classification between healthy and pathological gait stride interval. The stride-to-stride fluctuations and the swing intervals of 16 healthy control and 13 ALS-affected subjects were analyzed. Three features that are representative of the gait signal characteristics were extracted from the AD-space and are fed to linear discriminant analysis and neural network classifiers, respectively. Overall, maximum accuracies of 89.2% (LDA) and 100% (NN) were obtained in classifying the ALS gait.

During cardiac resuscitation from ventricular fibrillation (VF) it would be helpful if we could monitor and predict the optimal state of the heart to be shocked into a perfusing rhythm. Real-time feedback of this state to the emergency medical staff (EMS) could improve the survival rate after resuscitation. In this paper, using real world out-of-the-hospital human VF data obtained during resuscitation by EMS personnel, we present the results of applying wavelet markers in predicting the shock outcomes. We also performed comparative analysis of 5 existing techniques (spectral and correlation based approaches) against the proposed wavelet markers. A database of 29 human VF tracings was extracted from the defibrillator recordings collected by the EMS personnel and was used to validate the waveform markers. The results obtained by the comparison of the wavelet based features with other spectral, and correlation-based features indicates that the proposed wavelet features perform well with an overall accuracy of 79.3% in predicting the shock outcomes and hence demonstrate potential to provide near real-time feedback to EMS personnel in optimizing resuscitation outcomes.

Research in signal processing shows that a variety of transforms have been introduced to map the data from the original space into the feature space, in order to efficiently analyze a signal. These techniques differ in their basis functions, that is used for projecting the signal into a higher dimensional space. One of the widely used schemes for quasi-stationary and non-stationary signals is the time-frequency (TF) transforms, characterized by specific kernel functions. This work introduces a novel class of Ramanujan Fourier Transform (RFT) based TF transform functions, constituted by Ramanujan sums (RS) basis. The proposed special class of transforms offer high immunity to noise interference, since the computation is carried out only on co-resonant components, during analysis of signals. Further, we also provide a 2-D formulation of the RFT function. Experimental validation using synthetic examples, indicates that this technique shows potential for obtaining relatively sparse TF-equivalent representation and can be optimized for characterization of certain real-life signals.

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