Various plant extracts have currently been used in the bioproduction of nanoparticles with enormous applications. In this study, Rauvol a tetraphylla ower extracts were employed to obtain silver nanoparticles (Ag NPs) in bioproduction. The biologically produced nanoparticles were characterized by XRD, FTIR, UV-Vis, BET, SEM, EDXA, and TEM analyses. Phytochemical screening of the Rauvol a tetraphylla ower extracts indicated presence of 9 di erent constituents. Bioreduction of Ag NPs by phytochemicals was revealed by FTIR analysis. The elemental composition of Ag NPs was reported by spectral EDXA. The Ag NPs exhibited anti-bacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella aerogenes, and Escherichia coli; anti-fungal activity against Penicillium citrinum and Aspergillus avus; and antimitotic activity. The response of amines in formic acid in the presence of an Ag NPs catalyst in dissolvable free condition provided high yielded convention for the N-formylation to shape the comparing formamide derivatives. N-fromylation had the characteristics of incite recyclability, clean strategy, environmental friendliness under milder response conditions, and straightforward work-up with brilliant yield of the coveted items.

Abstract. N a -protected ureidopeptides were e ciently synthesized using bromodimethylsulfonium bromide mediated Curtius rearrangement through the in-situ generation of carboxylated sulfonium intermediate. Conversion of carboxylic acids to ureidopeptides in good yield was achieved in one pot under mild reaction conditions through a simple workup. To check the binding modes and binding a nity of urea functional group with target protein, the synthesized compounds were subjected to docking studies. Docking scores con rmed that the Boc-Leu-[NHCONH]-Ala-OMe and Leu-[NHCONH]-Ala-OMe molecules had the lowest energy and good agreement with the results of antibacterial studies against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeroginosa in comparison with streptomycin sulphate as a standard. The synthesized compounds were well characterized by IR, 1 H NMR, 13 C NMR, and mass spectral studies.