No abstract

Ameloblastoma is the most common neoplasm affecting the jaws, arising from the odontogenic epithelium. Despite its locally aggressive nature, it is considered to be benign. The chief histopathological variants of ameloblastoma are the follicular and plexiform types, followed by the acanthomatous and granular cell types. Uncommon variants include desmoplastic, basal cell, clear cell ameloblastoma, keratoameloblastoma and papilliferous keratoameloblastoma. When the desmoplastic type co-exists with other types, it is called as "hybrid" ameloblastoma. There are significant anatomic, histopathological and radiological differences between desmoplastic ameloblastoma and the classical type. The purpose of this article is to report a case and to review the relevant literature, emphasizing peculiar aspects of this unusual lesion.

Aim: The aim of this study was to evaluate the syndecan-1 expression in oral submucous fibrosis (OSF) according to grades of epithelial dysplasia. Materials and Methods: Twenty samples of OSF were divided into three groups: Group 1 (OSF with mild epithelial dysplasia, n = 15), Group 2 (OSF with moderate epithelial dysplasia, n = 3), and Group 3 (OSF with severe epithelial dysplasia, n = 2). Results: A statistically nonsignificant (P > 0.05) difference was noted when staining intensity of syndecan-1 in stratum basale were compared between OSF with mild dysplasia (O1) and OSF with moderate dysplasia (O2) (P = 0.141), O1 and OSF with severe dysplasia (O3) (P = 0.222) also between O2 and O3 (P = 1.00). A statistically significant (P < 0.05) difference was noted when staining intensity of syndecan-1 in stratum spinosum were compared between O1 and O2 (P = 0.010), O1 and O3 (P = 0.038), between O2 and O3 the difference was not statistically significant (P = 0.414). A statistically nonsignificant difference was noted when intensity of syndecan-1 expression in superficial layers of the epithelium was compared between O1 and O2 (P = 0.655), O1 and O3 (P = 0.715), also when O2 and O3 were compared, the difference was not statistically significant (P = 1.00). Conclusion: Downregulation of syndecan-1 antigen in OSF according to increased grades of epithelial dysplasia correlates to some extent with the disease progression.

Background: Grinspan syndrome is characterised by presence of the triad: hypertension, diabetes mellitus (DM) and oral lichen planus (OLP). OLP, seen in hypertension and diabetes mellitus, is caused by drugs used to treat these diseases according to literature, however the incidence of this syndrome in India has not yet been reported anywhere. Hence the present study was conducted with the following objectives: (i) To determine the incidence of Grinspan syndrome amongst tribal and suburban study population of Maharashtra in different gender and age groups (ii) To correlate occurrence of OLP with DM type 2 and hypertension (iii) To find out the number of patients with OLP, DM type 2 and hypertension either alone or in combination. Methods and Material: The present study was conducted on 4681 new patients attending the routine outpatient department (O.P.D.) of the dental hospital between January 2017 and December 2018. Patients with OLP or DM (type-2) or hypertension or any combination of these diseases were included in the present study. Brief case history of each patient was recorded. Data thus collected were analysed using SPSS version 20 for Chi-square test. Results: Grinspan syndrome was found in 1.62% of the study population. Syndrome was seen in 1.02% of female and 0.59% of male. Maximum patient affected by syndrome were in 35-50 years of age group. Conclusions: Incidence of Grinspan syndrome was 1.62%, mainly seen in sub-urban females of 35-50 years and OLP seen in hypertension and diabetes mellitus has different etiology and is not caused by drugs used to treat these diseases.