No abstract

Background: COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality. Objective: This study aims to determine the differences in the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients compared to non-COVID-19 patients. This study also aimed to analyze the correlation between the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients. Methods: This research is an observational analytic study with crosssectional approach. The samples were 15 paraffin blocks of post-mortem lung tissue biopsy of COVID-19 patients, and 15 paraffin blocks of inflammatory lung tissue biopsy or surgery of non-COVID-19 patients. IL-6 and IL-17 expressions were evaluated by immunohistochemical procedure. Result: There was a significant difference in the expression of IL-6 in the COVID-19 group and the non-COVID-19 group with a p-value = 0.001 (p < 0.05). There was a significant difference in the expression of IL-17 in the COVID-19 group and the non-COVID-19 group with p-value = 0.001 (p < 0.05). There was a significant correlation between the expressions of IL-6 and IL-17 in the COVID-19 group, with the Spearman coefficient value (rs) of 0.548 with p = 0.034 (p < 0.05). Conclusion: There are differences in the expression of IL-6 and IL-17 between COVID-19 and non-COVID-19 lung tissue. There is a significant correlation between the expressions of IL-6 and IL-17 in post-mortem lung tissue of COVID-19 patients.

No abstract

No abstract

In myocardial infarct patient with heart failure, left ventricular (LV) function evaluation after myocardial infarction provides prognostic information. However, the relationship between exercise capacity and LV function has not been fully explored. This study aims to analyze the correlation of LV function with functional capacity in acute myocardial infarct patient with heart failure. From 33 patients who fulfilled the inclusion and exclusion criteria, treadmill and echocardiography were examined (LVEDd, myocardial performance index (MPI), E/E’ diastolic function, LV Stiffness). The results are then statistically analyzed using SPSS. The mean LV ejection fraction is 44.27 ± 9.0% by Teich, and 40.55 ± 8.3% by Biplane. The value of the global MPI function is (0.60-0.90). The average E/A ratio is 1.0 ± 0.5, deceleration time (DT) is > 220m / sec, and E / E ratio is 11.46 ± 5.82ms. The functional capacity value is 3.4 (1.1-8.4) METS. There is a significant positive correlation of LV systolic function and functional capacity and significant negative correlation between MPI and functional capacity in myocardial infarct patients with heart failure. Furthermore, there is a non-significant correlation between diastolic function and functional capacity.