No abstract

To assess the antimicrobial activity and the physical properties of resin-based experimental endodontic sealers with the incorporation of vegetable extracts obtained from Bixa orellana, Mentha piperita, and Tagetes minuta species. The extracts were obtained and characterized by gas chromatography-mass spectrometry (GC–MS), and minimum inhibitory concentration (MIC) against Streptococcus mutans, Enterococcus faecalis, and Candida albicans. The extracts were individually incorporated into a dual-cure experimental sealer at a mass concentration of 0.5%. A commercial reference RealSeal was used. The sealers were evaluated by measuring the setting time, degree of conversion, dimensional stability, radiopacity, flow, and film thickness of these materials, also and its antimicrobial effect was evaluated using the direct contact test. Data were statistically analyzed by analysis of variance and Tukey’s post-hoc test at α = 0.05 significance level. The physical properties were not influenced by the addition of the vegetable extracts (p > 0.05). For S. mutans, only T. minuta and B. orellana groups presented antibacterial activity after 24 h of contact (p < 0.05). All extracts evidenced an antibacterial effect against E. faecalis (p < 0.05). The experimental sealers hold promise as a novel vegetable sealer with great antimicrobial activity and also great physical–mechanical properties. Nonetheless, more studies are needed.

The Butia sp. are native South America trees, whose fruits are consumed in natura and have significant biological properties; however, trees of this genus plant are in danger of extinction. A systematic review of the literature and a technological overview were carried out to summarize the available evidence on the therapeutic uses and the phytochemical compounds of Butia sp. The following electronic databases were researched: MedLine (PubMed), Web of Science, Scopus, Scielo, and the gray literature. Furthermore, the online system such as the US Patent and Trademark Office, Espacenet, National Institute of Industrial Property, and Google Patents were accessed to obtain patent data. The inclusion criteria were articles that describe either the therapeutic uses of Butia sp. (antimicrobial activity, antioxidant activity, anti-inflammatory activity, antineoplastic activity) or studies describing phytochemical compounds of Butia sp. A limited amount of manual search was also undertaken. Reference lists were scanned to identify other relevant studies, and requests for unpublished data were conducted to people working in the field. Among 12 papers and 14 patents, 9 complete texts of scientific articles and 1 patent were scrutinised by two reviewers. We concluded that Butia has shown some antioxidant, anti-inflammatory, and antimicrobial activity, and its use could have important implications for future therapeutic uses. Although there is evidence of pharmacological potential from in vitro studies, clinical studies must be conducted to confirm the effectiveness of Butia sp. The evidence of its therapeutic uses has not been extensively studied yet, and the available evidence still needs further confirmation. Copyright © 2017 John Wiley & Sons, Ltd.

ResumoO objetivo deste estudo foi avaliar as propriedades físico-químicas e antimicrobianas de um cimento endodontico resinoso contendo óleo de copaíba. Os cimentos foram formulados em três concentrações do óleo (0,5%, 1% e 2%). O grupo de controle negativo foi um cimento sem óleo e o comercial Real Seal® (Sybronendo, Orange, EUA). O controle positivo foi o inóculo bacteriano. A atividade antimicrobiana foi avaliada através da determinação da concentração inibitória mínima (MIC) e frente aos testes de contato direto (TCD). Para avaliar as propriedades físico-químicas foram realizados os ensaios de escoamento, alteração dimensional, tempo 24h contra E. faecalis, no teste contra S. aureus os cimentos contendo o oleo são superiores ao comercial em 24h. O escoamento e a alteração dimensional foram semelhantes ao cimento comercial, o tempo de presa e grau de conversão foram maior do que o comercial, somente a radiopacidade obteve resultado inferior. Logo, os cimentos contendo óleo de copaíba revelaram atividade antimicrobiana em 24h em todas as concentrações testadas. Em especial, o cimento contendo 0,5% de copaíba. No entanto, é

No abstract