No abstract

Polyurethane foams have been studied as drug carrier matrixes for sustained delivery application. The drugs used in the investigation were the specific antituberculous drug isoniazid, the antibiotic rifampicin, and the local anaesthetic novocain. The release of the drugs into model biological media was studied by UV spectroscopy. It has been found that drug release occurs in accordance with first‐order kinetics. The possibility of application of drug delivery systems for treatment of tuberculosis and haemorrhoids has been shown by some medical‐biological tests.

Development and characterization of new medication forms of analgesic drugs is an important current problem of pharmacy. In this connection, special attention is drawn to the buecal medication form (BMF) of drugs, whereby a drug is applied to the mucous membrane in the oral cavity [1,2]. Drugs used in the buccal form readily penetrate into the systemic blood circulation system, by-passing the liver and, hence, being not subject to the liver metabolism. BMF preparations are usually obtained on the basis of natural and synthetic polymers [3,4].Prosidol is an efficient narcotic analgesic drug approved for clinical use in I% solution for injections and 0.025 g tablets [5]. Due to its relatively short period of action, prosidol requires repeated administration for pain, which is associated with a certain discomfort.In order to prolong the analgesic activity of prosidol, we have synthesized and studied BMF prosidol preparations