Drug Delivery Systems for Tuberculosis Treatment

Batyrbekov, Erkesh O.; Rukhina, Larisa B.; Zhubanov, B. A.; Bekmukhamedova, Nailya F.; Smailova, Gulnara A.

doi:10.1002/(sici)1097-0126(199708)43:4<317::aid-pi741>3.0.co;2-w

“…The reaction proceeded at 110–115°C for 2 h in the argon flow. A prepolymer with isocyanate end groups was obtained where the percentage of isocyanate was determined, as mentioned elsewhere 14.…”

Section: Methodsmentioning

confidence: 99%

Preparation and release profiles of cyclophosphamide from segmented polyurethanes

Iskakov¹,

Batyrbekov²,

Leonova³

et al. 2000

J. Appl. Polym. Sci.

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Supermolecular structure of drug delivery system on the basis of segmented polyurethane (SPU) has been determined to control the release of anticancer drug, cyclophosphamide (CPh). It has been established that the phase separation in SPU is essentially intensified by means of both the increase of molecular weight for SPU's soft segments and CPh incorporation in the monolithic systems of polyethylene glycol-based polyurethane. Infrared and proton NMR data indicate that CPh is hydrogenicly associated with a urethane group of hard segments. It has been determined that the drug-concentrated domains of hard segments are microheterogeneously dispersed in the amorphous soft segments. These results indicate that a supermolecular structure design of SPU allows for control of the CPh release from the polymer matrix. Medicalbiological tests of the prepared polyurethane device have shown reduced toxic action of the cytostatic drug compared with injections.

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“…untreated 11 . 2 mm) (Batyrbekov et al, 1997) The values of weight loss and ulcer dimensions in the place of infection in animals of the another groups are following: 8 . 6% and 4 .…”

Section: Polyurethane Foams As Carriers Of Antituberculosis Drugsmentioning

confidence: 99%

Polyurethane as Carriers of Antituberculosis Drugs

Batyrbekov¹,

Iskakov²

2012

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“…A prepolymer with isocyanate end groups was obtained where the percentage of isocyanate was determined, as mentioned elsewhere. 14 Polyurethane films were prepared by a reaction between the isocyanate terminal groups of prepolymer and diethylene glycol as a chain extender. A 1.0-g shot of the prepolymer, 0.06 g diol (NCO : OH molar of 1 : 1.2), and the drug substance as fine crystals containing 20 mg of the drug/1 g polyurethane (20 mg/g) were successively dissolved in dimethyl sulphoxide solvent.…”

Section: Synthesis Of Segmented Polyurethanementioning

confidence: 99%

Preparation and release profiles of cyclophosphamide from segmented polyurethanes

Iskakov¹,

Batyrbekov²,

Leonova³

et al. 2000

J. Appl. Polym. Sci.

Self Cite

View full text Add to dashboard Cite

Supermolecular structure of drug delivery system on the basis of segmented polyurethane (SPU) has been determined to control the release of anticancer drug, cyclophosphamide (CPh). It has been established that the phase separation in SPU is essentially intensified by means of both the increase of molecular weight for SPU's soft segments and CPh incorporation in the monolithic systems of polyethylene glycol-based polyurethane. Infrared and proton NMR data indicate that CPh is hydrogenicly associated with a urethane group of hard segments. It has been determined that the drug-concentrated domains of hard segments are microheterogeneously dispersed in the amorphous soft segments. These results indicate that a supermolecular structure design of SPU allows for control of the CPh release from the polymer matrix. Medicalbiological tests of the prepared polyurethane device have shown reduced toxic action of the cytostatic drug compared with injections.

show abstract

Drug Delivery Systems for Tuberculosis Treatment

Cited by 12 publications

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Preparation and release profiles of cyclophosphamide from segmented polyurethanes

Preparation and release profiles of cyclophosphamide from segmented polyurethanes

Polyurethane as Carriers of Antituberculosis Drugs

Preparation and release profiles of cyclophosphamide from segmented polyurethanes

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