Ascorbic acid (AA), a plasma antioxidant, is maintained at high levels in premature fetal blood and declines rapidly postpartum. The sudden reduction in blood AA levels secondary to premature delivery may increase the risk of oxidant injury, that is, bronchopulmonary dysplasia and intraventricular hemorrhage. There is concern that administration of AA to premature infants, in an effort to increase antioxidant capacity, may cause hemolysis. We felt that the benefits of early AA administration and prevention of the immediate postnatal drop in blood AA levels, might outweigh the risks of erthrocyte damage. Fifty one high-risk premature infants were randomized to receive either normal saline or 100 mg/kg of AA, daily for the first week of life. Double-blind comparisons were made of hemoglobin, hematocrit, erythrocyte morphology, bilirubin, number of blood transfusions and days of phototherapy, renal function tests, the incidence of infection, bronchopulmonary dysplasia, and intraventricular hemorrhage during the first month of life. The administration of AA prevented the immediate postnatal drop in AA and was not associated with evidence of increased hemolysis. No significant differences in renal function, rate of infection, bronchopulmonary dysplasia, or intraventricular hemorrhage were seen between the two groups. This study suggests that AA administration to the premature infant is safe and supports the designing and performance of larger clinical studies of the antioxidant properties of AA.
SummaryThis re-survey of neurosurgical centres was conducted to determine whether the publication of management guidelines has resulted in changes in the intensive care management of severely headinjured patients (defined as Glasgow Coma Score , 9) in the UK and Ireland. Results were compared with data collected from a similar survey conducted 2 years earlier. Almost 75% of centres monitor intracranial pressure in the majority of patients and 80% now set a target cerebral perfusion pressure of . 70 mmHg. The use of prolonged hyperventilation (. 12 h) is declining and the target P a co 2 is now most commonly . 4 kPa. More centres maintain core temperature , 36.5 8C. Although wide variations in the management of severely head-injured patients still exist, we found evidence of practice changing to comply with published guidelines. In surveys carried out 2 years ago, we highlighted the wide variation in the intensive care management of severely head-injured patients [defined as Glasgow Coma Score (GCS) , 9] in neurosurgical centres throughout the UK and Ireland [1, 2]. Since these initial surveys, two expert bodies have produced guidelines for the management of severe head injury [3, 4]. We surveyed neurosurgical centres to examine whether the management of severely head-injured patients had changed following publication of these guidelines. MethodsThe directors of 44 neurosurgical centres in the UK and Ireland were asked to complete a questionnaire identical to that used 2 years earlier. After 4 weeks, a copy of the questionnaire was sent to all non-responders with a covering letter urging them to reply. The data collected in this survey were compared with results obtained 2 years ago using a Chi-squared test. The significance level was set at 0.05 and statistical analysis was performed using statview 4.0 (Abacus Concepts Inc., Berkeley, CA, USA). ResultsAll 44 centres replied, but four of these did not treat severely head-injured patients and so were not analysed further. Compared with 1996, a greater proportion of units had dedicated junior staff (87 vs. 66%; Chisquared 13, d.f. 1, p , 0.05) and identifiable high-dependency unit (HDU) facilities (68 vs. 43%; Chi-squared 17, d.f. 1, p , 0.05). Only 54% of units had a written protocol for the management of raised intracranial pressure. The changes in management that we observed between the two survey periods are listed in Tables 1±3. DiscussionRecent guidelines [3, 4] suggest monitoring intracranial pressure (ICP) in all patients with a GCS , 9 or an abnormal computed tomography scan. Mean arterial pressure (MAP) should be maintained . 90 mmHg and cerebral perfusion pressure (CPP) . 70 mmHg. Intracranial hypertension should be treated when ICP is . 25 mmHg. The guidelines advise against severe or prolonged hyperventilation and found no evidence to support the use of steroids in head injury. The availability of these guidelines appears to have altered ICU care for severely head-injured patients.Organisational changes in admission practice, unit staffing and HDU bed...
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