A malignant dendritic melanoma of the oral cavity with metastases widely spread in a cow is described. The clinicopathological manifestations, developed during a two-year period, was characterized by the difficulty in mastication and swallowing, progressive weight loss, weakness and profuse sialorrhea. At the necropsy, an ulcerated black mass was found at the left jaw projecting into the oral cavity. The tumor reached the chin, inferior lip and tongue. Metastases were detected within the tongue, parotid gland, lymph nodes, trachea, thyroid, pleura, lungs, heart, peritoneum, omentum, and serosal membranes of the forestomach and abomasum, liver, and intima of some hepatic vessels, mammary gland, and muscles and fasciae of the left hind leg. No reference to metastasizing oral dendritic melanoma in the oral cavity of the cattle has been mentioned in the literature.

Pesq. Vet. Bras. 31(11):938-952, novembro 2011 938 Efeito protetor da acetamida sobre as intoxicações experimentais em ratos por monoϐluoroacetato de sódio e por algumas plantas brasileiras que causam morte súbita 1 Amorimia (Mascagnia) exotropica and M. aff. rigida) was studied using rats. Additionally the clinical and pathological picture of the poisoning was described. In these experiments 33 Wistar rats (Rattus norvegicus albinus) were used. Nine rats ate spontaneously the fresh leaves of P. marcgravii at amounts of 2.0 and 4.0g/kg. Two of the rats received orally single doses of acetamide (2.0 and 4.0g/kg) one minute before the plant was supplied. A third rat received 4.0g/kg of acetamide after consumption of 4.0g/kg of the plant and showed severe symptoms of poisoning. In the experiments with MF, doses of 4.0 and 8.0mg/kg were administered to four rats. The interval between the administration of either acetamide and concentrated plant extracts or MF ranged from 2 to 4 hours; the dose of acetamide ranged from 2.0 to 8.0g/ kg. In the experiments with concentrated extracts of eight BSDCP, 20 rats were orally poisoned with single or repeated doses. Acetamide, when previously administered, prevented the appearance of clinical signs and death in all of the rats poisoned by MF, as well as of the ones poisoned by fresh P. marcgravii leaves and by the concentrated extracts of each of the other BSDCP. These rats were re-subjected to the same experimental protocol, yet without the administration of acetamide. In these experiments, all of the rats evidenced clinical signs and death (except M. aff. rigida). All of the rats showed mild to markedly engorged atria, and sometimes also of the cranial and caudal vena cava. In three of the rats, there was a moderate right and left cardiac dilatation. The liver of all rats was slightly or markedly congested, with lobular pattern in some. There was frothy liquid on the cut surface of the lungs in three of the rats. The histopathology of the kidneys in six rats showed slight cytoplasmic swelling of the distal convoluted tubules and sometimes also of the collecting tubules. But only in four rats a vacuolar-hydropic degeneration with nuclear pyknosis was seen. Twenty-six rats showed liver congestion, three of them with compressive narrowing of the hepatic cords, and in eight Efeito da acetamida sobre a intoxicação experimental em ratos por monoϐluoroacetato de sódio e por plantas brasileiras rats shock corpuscles were observed; another three rats showed slight to moderate focal liver necrosis. A slight to moderate vacuolation of hepatocytes was observed in 16 rats. It can be concluded that acetamide had a protective effect, capable to prevent clinical signs and death of the rats poisoned by MF, and by fresh P. marcgravii leaves and concentrated extracts of seven other BSDCP. The clinical and pathological picture observed in the rats poisoned by MF and BSDCP, associated with the protective effect of acetamide, indicate that MF is the toxic principle responsible for death of ...

As folhas recém-colhidas de Jatropha gossypifolia (Euphorbiaceae) foram letais para ovinos em administrações únicas de 40g/kg. A dose de 5g/kg não causou sintomas de intoxicação; as doses intermediárias provocaram a morte de parte dos animais. A evolução da intoxicação foi de 6 a 22 dias. O quadro clínico-patológico nos ovinos experimentais era caracterizado por perturbações digestivas, pulmonares, cardíacas e ainda alterações regressivas leves somente evidenciadas através de exames histológicos, hepáticas e renais. Esses achados são semelhantes aos observados em experimentos com as sementes de Jatropha curcas em caprinos, ovinos e bezerros, e com os com os frutos e as folhas de Jatropha glauca e Jatropha aceroides em caprinos, realizados por outros autores. Estas comparações indicam que, independentemente das espécies, as folhas de Jatropha spp. devem conter compostos semelhantes aos encontrados nas sementes.

IVCriptococose pulmonar associada à infecção sistêmica por Corynebacterium pseudotuberculosis em cabra (Capra hircus)

RELATO DE CASOCopyright Veiga et al. Este é um artigo publicado em acesso aberto (Open Access) sob a licença Creative Commons Attribution Non-Commercial, que permite uso, distribuição e reprodução em qualquer meio, sem restrições desde que sem fins comerciais e que o trabalho original seja corretamente citado. Mucopolissacaridose em um cão: relato de caso ResumoA Mucopolissacaridose é uma doença rara, multissistêmica, progressiva e sem tratamento. Os objetivos deste estudo foram descrever os achados clínicos, radiográficos e anátomo-patológicos de um caso de mucopolissacaridose em um cão. Relata-se um caso de um cão, macho, Fox Paulistinha, de quatro meses de idade, oriundo de cruzamento com alto grau de endogamia. O cão apresentava apatia, dificuldades de locomoção, aumento de volume nas articulações, opacidade de córnea e dispneia inspiratória. Ao exame radiográfico observaram-se alterações bilaterais em linhas fiseais de vértebras, rádio e ulna, hepatomegalia e hipoplasia traqueal. Devido à acentuada dificuldade respiratória, o proprietário optou pela eutanásia. À necropsia, observou-se ausência das cartilagens da laringe, cricoide e aritenoide, coração globoso, e fígado e baço moderadamente aumentados. As alterações ósseas incluíram aumento do perímetro do crânio, má formação do esterno e costelas sinuosas. A histopatologia revelou displasia nas cartilagens da epiglote, da traqueia e articulares, nas quais os condrócitos apresentavam-se com citoplasma vacuolizado; havia ainda acentuado espessamento da íntima da aorta. O histórico de cruzamentos com alto grau de endogamia, associado aos achados clínicos, radiográficos e anátomo-patológicos confluem para o diagnóstico de mucopolissacaridose.Palavras-chave: canino, disostose multiplex, enzimas lisossomais. AbstractMucopolysaccharidosis is a rare, multisystemic, progressive disease that has no cure. The objectives of this study were to describe the clinical, radiographic and anatomical and pathological findings of a case of mucopolysaccharidosis in a dog. It reports the case of a male dog of the Fox Paulistinha (Brazilian Terrier) breed, four months of age, derived from cross-breeding with high degree of endogamy. The animal exhibited apathy, walking difficulty, enlarged joints, opacity of the cornea, and inspiratory dyspnea. On X-ray, bilateral changes were observed in the physeal lines of vertebrae, radius and ulna, as well as enlarged liver and tracheal hypoplasia. Due to the accentuated respiratory difficulty, the owner decided to euthanize the dog. Necropsy showed the absence of the larynx, cricoid and arytenoid cartilages, a distended heart, and moderately enlarged liver and spleen. Bone changes included increased cranial perimeter, malformation of the sternum, and twisted ribs. Histopathology revealed dysplasia in the cartilage of the epiglottis, trachea and joints, in which the chondrocytes presented with vacuolated cytoplasm; there was also accentuated thickening of the aortic intima. The history of cross-breeding with a high degree of endogamy, associ...